TY - JOUR
T1 - Role of apoptosis in pancreatic β-cell death in diabetes
AU - Chandra, Joya
AU - Zhivotovsky, Boris
AU - Zaitsev, Sergei
AU - Juntti-Berggren, Lisa
AU - Berggren, Per Olof
AU - Orrenius, Sten
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Apoptosis is a physiological form of cell death that occurs during normal development, and critical mediators of this process include caspases, reactive oxygen species, and Ca2+. Excessive apoptosis of the pancreatic β-cell has been associated with diabetes. Consequently, apoptosis research has focused on how infiltrating macrophages or cytotoxic T-cells might kill pancreatic β-cells using cytokines or death receptor triggering. Meanwhile, the intracellular events in the target β-cell have been largely ignored. Elucidation of such targets might help develop improved treatment strategies for diabetes. This article will outline recent developments in apoptosis research, with emphasis on mechanisms that may be relevant to β-cell death in type 1 and type 2 diabetes. Several of the models proposed in β-cell killing converge on Ca2+ signaling, indicating that the pancreatic β-cell may be an ideal system in which to carefully dissect the role of Ca2+ during apoptosis.
AB - Apoptosis is a physiological form of cell death that occurs during normal development, and critical mediators of this process include caspases, reactive oxygen species, and Ca2+. Excessive apoptosis of the pancreatic β-cell has been associated with diabetes. Consequently, apoptosis research has focused on how infiltrating macrophages or cytotoxic T-cells might kill pancreatic β-cells using cytokines or death receptor triggering. Meanwhile, the intracellular events in the target β-cell have been largely ignored. Elucidation of such targets might help develop improved treatment strategies for diabetes. This article will outline recent developments in apoptosis research, with emphasis on mechanisms that may be relevant to β-cell death in type 1 and type 2 diabetes. Several of the models proposed in β-cell killing converge on Ca2+ signaling, indicating that the pancreatic β-cell may be an ideal system in which to carefully dissect the role of Ca2+ during apoptosis.
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U2 - 10.2337/diabetes.50.2007.s44
DO - 10.2337/diabetes.50.2007.s44
M3 - Article
C2 - 11272200
AN - SCOPUS:0035128535
VL - 50
SP - S44-S47
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - SUPPL. 1
ER -