Role of apoptosis in HIV disease pathogenesis

Naoki Oyaizu, Savita Pahwa

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity.

Original languageEnglish (US)
Pages (from-to)217-231
Number of pages15
JournalJournal of Clinical Immunology
Volume15
Issue number5
DOIs
StatePublished - Sep 1 1995
Externally publishedYes

    Fingerprint

Keywords

  • apoptosis
  • Bel-2
  • cytokine
  • cytopathicity
  • Fas
  • HIV-1
  • pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this