Role of Antinuclear Antibodies in Primary Biliary Cholangitis

Cynthia Levy, Christopher L. Bowlus

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


The identification of antinuclear antibodies specific for primary biliary cholangitis (PBC) has facilitated diagnosis in antimitochondrial antibody-negative individuals. Their presence may also have prognostic implication. In this edition of The American Journal of Gastroenterology, Reig et al. evaluate the frequency of PBC-specific antinuclear antibodies, their natural course and association with outcomes in 254 patients with PBC. Antibodies remained stable over time, and presence of antihexokinase1 and anti-sp100 was associated with shorter survival. Clinicians can request testing for PBC-specific antinuclear antibodies to minimize need for liver biopsy, but further research is needed to understand their role in disease prognostication.

Original languageEnglish (US)
Pages (from-to)1604-1606
Number of pages3
JournalThe American journal of gastroenterology
Issue number10
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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