Role of adhesion substrates in controlling endothelial cell function

P. D. Drumheller, N. P. Desai, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In this study we analyze the possibility that endothelial cells grown on adhesion peptide-grafted substrates may exhibit altered physiological responses to microinjuries. Peptide-grafted substrates show considerable potential for use as materials that support and promote endothelialization. The REDV substrate can support endothelial cell-specific adhesion and proliferation, and REDV-, RGD-, and YIGSR-supported endothelial monolayers all appeared to maintain their nonthrombogenic properties. By contrast, PDSGR-supported monolayers were very thrombogenic. These results illustrate the important influences that adhesion substrates exert upon endothelial cell function.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Place of PublicationAlgonquin, IL, United States
PublisherPubl by Soc for Biomaterials
Volume14
StatePublished - Jan 1 1991
Externally publishedYes
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

ASJC Scopus subject areas

  • Materials Science(all)

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    Drumheller, P. D., Desai, N. P., & Hubbell, J. A. (1991). Role of adhesion substrates in controlling endothelial cell function. In Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 14). Publ by Soc for Biomaterials.