Rodent spinal cord demyelination models

Sarah Jernigan, Yi Ping Zhang, Christopher B. Shields, Scott R. Whittemore

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

Original languageEnglish (US)
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Pages471-478
Number of pages8
ISBN (Print)9781603271844
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Demyelinating Diseases
Spinal Cord Injuries
spinal cord
lesions (animal)
Multiple Sclerosis
Rodentia
Spinal Cord
rodents
Guidelines
Wounds and Injuries
sclerosis
therapeutics
Therapeutics
cells

Keywords

  • Cuprizone
  • Demyelination
  • Ethidium bromide
  • Lysolethicin
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

Cite this

Jernigan, S., Zhang, Y. P., Shields, C. B., & Whittemore, S. R. (2009). Rodent spinal cord demyelination models. In Animal Models of Acute Neurological Injuries (pp. 471-478). Humana Press. https://doi.org/10.1007/978-1-60327-185-1_40

Rodent spinal cord demyelination models. / Jernigan, Sarah; Zhang, Yi Ping; Shields, Christopher B.; Whittemore, Scott R.

Animal Models of Acute Neurological Injuries. Humana Press, 2009. p. 471-478.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jernigan, S, Zhang, YP, Shields, CB & Whittemore, SR 2009, Rodent spinal cord demyelination models. in Animal Models of Acute Neurological Injuries. Humana Press, pp. 471-478. https://doi.org/10.1007/978-1-60327-185-1_40
Jernigan S, Zhang YP, Shields CB, Whittemore SR. Rodent spinal cord demyelination models. In Animal Models of Acute Neurological Injuries. Humana Press. 2009. p. 471-478 https://doi.org/10.1007/978-1-60327-185-1_40
Jernigan, Sarah ; Zhang, Yi Ping ; Shields, Christopher B. ; Whittemore, Scott R. / Rodent spinal cord demyelination models. Animal Models of Acute Neurological Injuries. Humana Press, 2009. pp. 471-478
@inbook{d5d4c3e4c38146de8308a078bd7dac4a,
title = "Rodent spinal cord demyelination models",
abstract = "Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.",
keywords = "Cuprizone, Demyelination, Ethidium bromide, Lysolethicin, Spinal cord injury",
author = "Sarah Jernigan and Zhang, {Yi Ping} and Shields, {Christopher B.} and Whittemore, {Scott R.}",
year = "2009",
doi = "10.1007/978-1-60327-185-1_40",
language = "English (US)",
isbn = "9781603271844",
pages = "471--478",
booktitle = "Animal Models of Acute Neurological Injuries",
publisher = "Humana Press",

}

TY - CHAP

T1 - Rodent spinal cord demyelination models

AU - Jernigan, Sarah

AU - Zhang, Yi Ping

AU - Shields, Christopher B.

AU - Whittemore, Scott R.

PY - 2009

Y1 - 2009

N2 - Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

AB - Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

KW - Cuprizone

KW - Demyelination

KW - Ethidium bromide

KW - Lysolethicin

KW - Spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=84900588826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900588826&partnerID=8YFLogxK

U2 - 10.1007/978-1-60327-185-1_40

DO - 10.1007/978-1-60327-185-1_40

M3 - Chapter

SN - 9781603271844

SP - 471

EP - 478

BT - Animal Models of Acute Neurological Injuries

PB - Humana Press

ER -