Rodent spinal cord demyelination models

Sarah C. Jernigan, Yi Ping Zhang, Christopher B. Shields, Scott R. Whittemore

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

Original languageEnglish (US)
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Number of pages8
ISBN (Print)9781603271844
StatePublished - Dec 1 2009


  • Cuprizone
  • Demyelination
  • Ethidium bromide
  • Lysolethicin
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)


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