Rodent spinal cord demyelination models

Sarah C. Jernigan; Yi Ping Zhang; Christopher B. Shields; Scott R. Whittemore

doi:10.1007/978-1-60327-185-1_40

Rodent spinal cord demyelination models

Sarah C. Jernigan, Yi Ping Zhang, Christopher B. Shields, Scott R. Whittemore

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

Original language	English (US)
Title of host publication	Animal Models of Acute Neurological Injuries
Publisher	Humana Press
Pages	471-478
Number of pages	8
ISBN (Print)	9781603271844
DOIs	https://doi.org/10.1007/978-1-60327-185-1_40
State	Published - Dec 1 2009

Keywords

Cuprizone
Demyelination
Ethidium bromide
Lysolethicin
Spinal cord injury

ASJC Scopus subject areas

Neuroscience(all)
Agricultural and Biological Sciences(all)

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10.1007/978-1-60327-185-1_40

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abstract = "Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.",

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AB - Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.

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KW - Ethidium bromide

KW - Lysolethicin

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Rodent spinal cord demyelination models

Abstract

Keywords

ASJC Scopus subject areas

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