Rodent models of cerebral ischemia

Myron D. Ginsberg, Raul Busto

Research output: Contribution to journalReview article

552 Scopus citations

Abstract

The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury - both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relatively low cost, are highly suitable for the investigation of cerebral ischemia and have been widely employed for this purpose. We critically examine and summarize several rodent models of transient global ischemia, resulting in selective neuronal injury within vulnerable brain regions, and focal ischemia, typically giving rise to localized brain infarction. We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury.

Original languageEnglish (US)
Pages (from-to)1627-1642
Number of pages16
JournalStroke
Volume20
Issue number12
DOIs
StatePublished - Dec 1989

Keywords

  • Animal models
  • cerebral arteries
  • cerebral infarction
  • gerbils
  • rats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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