@article{37df447d0d9d41dc9f813752f1737c49,
title = "Robust single-cell DNA methylome profiling with snmC-seq2",
abstract = "Single-cell DNA methylome profiling has enabled the study of epigenomic heterogeneity in complex tissues and during cellular reprogramming. However, broader applications of the method have been impeded by the modest quality of sequencing libraries. Here we report snmC-seq2, which provides improved read mapping, reduced artifactual reads, enhanced throughput, as well as increased library complexity and coverage uniformity compared to snmC-seq. snmC-seq2 is an efficient strategy suited for large-scale single-cell epigenomic studies.",
author = "Chongyuan Luo and Angeline Rivkin and Jingtian Zhou and Sandoval, {Justin P.} and Laurie Kurihara and Jacinta Lucero and Rosa Castanon and Nery, {Joseph R.} and Ant{\'o}nio Pinto-Duarte and Brian Bui and Conor Fitzpatrick and Carolyn O{\textquoteright}Connor and Seth Ruga and {Van Eden}, {Marc E.} and Davis, {David A.} and Mash, {Deborah C} and Behrens, {M. Margarita} and Ecker, {Joseph R.}",
note = "Funding Information: Postmortem human brain tissues were obtained from the NIH NeuroBioBank at The University of Miami Brain Endowment Bank. We thank the donors and their families for their invaluable donations for the advancement of science. This work is supported by NIH BRAIN Initiative grants 5U01MH105985 (J.R.E. and M.M.B.), 5R21MH112161 (J.R. E. and M.M.B.), U19MH114831 (J.R.E.), and 1R21HG009274 (J.R.E.). J.R.E. is an investigator of the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-06355-2",
language = "English (US)",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}