Abstract
Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.
Original language | English (US) |
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Pages (from-to) | 223-230 |
Number of pages | 8 |
Journal | Nature Neuroscience |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)