Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline

Marie Pierre Furrer, Susan Kim, Brian Wolf, Akira Chiba

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found that the cell-surface molecules Frazzled and Robo work as guidance molecules not only for axons but also for dendrites as they navigate within the CNS. Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalNature Neuroscience
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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