RNAi as a potential new therapy for HIV infection

Lee A. Wheeler, Derek M. Dykxhoorn

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Controlling HIV infection continues to be a major clinical and scientific challenge. Despite the therapeutic benefits associated with HAART, the need for novel treatment approaches to combat HIV-1 remains. Effective inhibition of HIV-1 infection has been achieved by harnessing the endogenous RNAi pathway in a variety of cell types, including primary T cells and macrophages. Here we discuss the opportunities and challenges associated with translating these findings into clinically relevant therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalFuture HIV Therapy
Volume2
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Antiviral therapy
  • Genetic therapy
  • HIV-1
  • RNAi
  • Sirna

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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