TY - JOUR
T1 - RNAdb - A comprehensive mammalian noncoding RNA database
AU - Pang, Ken C.
AU - Stephen, Stuart
AU - Engström, Pär G.
AU - Tajul-Arifin, Khairina
AU - Chen, Weisan
AU - Wahlestedt, Claes
AU - Lenhard, Boris
AU - Hayashizaki, Yoshihide
AU - Mattick, John S.
N1 - Funding Information:
We thank Jeff McDonald and Steve Scherer for providing us with information on ncRNAs identified by the chromosome 7 annotation project, as well as Carole Charlier for providing us with information on callipyge locus ncRNAs. K.C.P. is supported by the NHMRC with a Postgraduate Medical Research Scholarship (234711). W.C. is supported by a Wellcome Trust International Senior Research Fellow Fellowship (066646Z01Z). J.S.M. is supported by the Australian Research Council and the Queensland State Government.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here, we describe the construction of a comprehensive mammalian noncoding RNA database (RNAdb) which contains over 800 unique experimentally studied non-coding RNAs (ncRNAs), including many associated with diseases and/or developmental processes. The database is available at http://research.imb.uq. edu.au/RNAdb and is searchable by many criteria. It includes microRNAs and snoRNAs, but not infrastructural RNAs, such as rRNAs and tRNAs, which are catalogued elsewhere. The database also includes over 1100 putative antisense ncRNAs and almost 20 000 putative ncRNAs identified in high-quality murine and human cDNA libraries, with more to be added in the near future. Many of these RNAs are large, and many are spliced, some alternatively. The database will be useful as a foundation for the emerging field of RNomics and the characterization of the roles of ncRNAs in mammalian gene expression and regulation.
AB - In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here, we describe the construction of a comprehensive mammalian noncoding RNA database (RNAdb) which contains over 800 unique experimentally studied non-coding RNAs (ncRNAs), including many associated with diseases and/or developmental processes. The database is available at http://research.imb.uq. edu.au/RNAdb and is searchable by many criteria. It includes microRNAs and snoRNAs, but not infrastructural RNAs, such as rRNAs and tRNAs, which are catalogued elsewhere. The database also includes over 1100 putative antisense ncRNAs and almost 20 000 putative ncRNAs identified in high-quality murine and human cDNA libraries, with more to be added in the near future. Many of these RNAs are large, and many are spliced, some alternatively. The database will be useful as a foundation for the emerging field of RNomics and the characterization of the roles of ncRNAs in mammalian gene expression and regulation.
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U2 - 10.1093/nar/gki089
DO - 10.1093/nar/gki089
M3 - Article
C2 - 15608161
AN - SCOPUS:13444293342
VL - 33
SP - D125-D130
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - DATABASE ISS.
ER -