Abstract
The endogenous RNA interference (RNAi) pathway regulates cellular differentiation and development using small noncoding hairpin RNAs, called microRNAs. This chapter will review the link between mammalian microRNAs and genes involved in cellular proliferation, differentiation, and apoptosis. Some microRNAs act as oncogenes or tumor suppressor genes, but the target gene networks they regulate are just beginning to be described. Cancer cells have altered patterns of microRNA expression, which can be used to identify the cell of origin and to subtype cancers. RNAi has also been used to identify novel genes involved in cellular transformation using forward genetic screening methods previously only possible in invertebrates. Possible strategies and obstacles to harnessing RNAi for cancer therapy will also be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 299-329 |
| Number of pages | 31 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 615 |
| DOIs | |
| State | Published - Jan 1 2008 |
| Externally published | Yes |
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Keywords
- Cancer
- Microarray
- MicroRNA
- Prognosis
- RNA interference
- SiRNA
- Therapy
- Tumor profile
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
RNA interference and cancer : Endogenous pathways and therapeutic approaches. / Dykxhoorn, Derek M; Chowdhury, Dipanjan; Lieberman, Judy.
In: Advances in Experimental Medicine and Biology, Vol. 615, 01.01.2008, p. 299-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - RNA interference and cancer
T2 - Endogenous pathways and therapeutic approaches
AU - Dykxhoorn, Derek M
AU - Chowdhury, Dipanjan
AU - Lieberman, Judy
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The endogenous RNA interference (RNAi) pathway regulates cellular differentiation and development using small noncoding hairpin RNAs, called microRNAs. This chapter will review the link between mammalian microRNAs and genes involved in cellular proliferation, differentiation, and apoptosis. Some microRNAs act as oncogenes or tumor suppressor genes, but the target gene networks they regulate are just beginning to be described. Cancer cells have altered patterns of microRNA expression, which can be used to identify the cell of origin and to subtype cancers. RNAi has also been used to identify novel genes involved in cellular transformation using forward genetic screening methods previously only possible in invertebrates. Possible strategies and obstacles to harnessing RNAi for cancer therapy will also be discussed.
AB - The endogenous RNA interference (RNAi) pathway regulates cellular differentiation and development using small noncoding hairpin RNAs, called microRNAs. This chapter will review the link between mammalian microRNAs and genes involved in cellular proliferation, differentiation, and apoptosis. Some microRNAs act as oncogenes or tumor suppressor genes, but the target gene networks they regulate are just beginning to be described. Cancer cells have altered patterns of microRNA expression, which can be used to identify the cell of origin and to subtype cancers. RNAi has also been used to identify novel genes involved in cellular transformation using forward genetic screening methods previously only possible in invertebrates. Possible strategies and obstacles to harnessing RNAi for cancer therapy will also be discussed.
KW - Cancer
KW - Microarray
KW - MicroRNA
KW - Prognosis
KW - RNA interference
KW - SiRNA
KW - Therapy
KW - Tumor profile
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U2 - 10.1007/978-1-4020-6554-5_14
DO - 10.1007/978-1-4020-6554-5_14
M3 - Article
VL - 615
SP - 299
EP - 329
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -