RNA interference and cancer: Endogenous pathways and therapeutic approaches

Derek M Dykxhoorn, Dipanjan Chowdhury, Judy Lieberman

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The endogenous RNA interference (RNAi) pathway regulates cellular differentiation and development using small noncoding hairpin RNAs, called microRNAs. This chapter will review the link between mammalian microRNAs and genes involved in cellular proliferation, differentiation, and apoptosis. Some microRNAs act as oncogenes or tumor suppressor genes, but the target gene networks they regulate are just beginning to be described. Cancer cells have altered patterns of microRNA expression, which can be used to identify the cell of origin and to subtype cancers. RNAi has also been used to identify novel genes involved in cellular transformation using forward genetic screening methods previously only possible in invertebrates. Possible strategies and obstacles to harnessing RNAi for cancer therapy will also be discussed.

Original languageEnglish
Pages (from-to)299-329
Number of pages31
JournalAdvances in Experimental Medicine and Biology
Volume615
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Keywords

  • Cancer
  • Microarray
  • MicroRNA
  • Prognosis
  • RNA interference
  • SiRNA
  • Therapy
  • Tumor profile

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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