Ritanserin, a 5-HT2 receptor antagonist, increases subcortical blood flow following photothrombotic middle cerebral artery occlusion in rats

Tobias Back, Ricardo Prado, Weizhao Zhao, Brant D. Watson, Myron D. Ginsberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

It has been proposed that the reversal of serotonin-mediated vasoconstriction accounts for the neuroprotective effect of serotonin (5- HT2) receptor blockade in focal cerebral ischemia. We investigated the effect of pretreatment with ritanserin, a 5-HT2 receptor antagonist, on cerebral blood flow in a model of photothrombotic middle cerebral artery occlusion in rats. Local cerebral blood flow was measured by iodoantipyrine autoradiography 30 minutes after induction of ischemia. Using a novel image- alignment algorithm, 3-dimensional reconstructions of averaged cerebral blood flow were calculated. The difference-image of local cerebral blood flow between ritanserin and vehicle-treated animals revealed a subcortical zone underlying the ischemic cortex where cerebral blood flow was markedly enhanced indicating a beneficial hemodynamic effect of ritanserin. Three- dimensional image analysis provides a powerful tool to detect inter-group differences of cerebral blood flow which are underestimated by conventional types of data analysis.

Original languageEnglish (US)
Pages (from-to)643-647
Number of pages5
JournalNeurological Research
Volume20
Issue number7
DOIs
StatePublished - Oct 1998

Keywords

  • 3D- reconstruction
  • Autoradiography
  • Cerebral blood flow
  • Focal ischemia
  • Image analysis
  • Serotonin antagonist

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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