Risks of Affective Illness Among First-Degree Relatives of Bipolar I Old-Order Amish Probands

David L. Pauls, Lois A. Morton, Janice A. Egeland

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Data from bipolar I old-order Amish families suggest that the morbid risk of illness is not significantly different in this population when compared with estimates of risk from previous studies. The age-corrected rates of bipolar I, bipolar II, and major depressive disorder among first-degree relatives are 8.7, 3.7, and 11.6, respectively. Risk of illness is not significantly different among male and female relatives and among relatives of male and female probands. Consistent with other reports, the rate of illness is higher among relatives of probands with early-onset disease. In contrast with previous reports, there does not appear to be a cohort effect in this population.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalArchives of General Psychiatry
Volume49
Issue number9
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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