Risks and benefits of Helicobacter pylori eradication: Current status

David Amstrong, Alan Barkun, Marcel Behr, Linda Best, Ted Bosworth, Marc Bradette, Ford Bursey, Hugh Chaun, Naoki Chiba, Alan Cockeram, Ken Croitoru, Carlo Fallone, Nigel Flook, Eric Hassall, Paul Hoffman, Jia Qing Huang, Richard Hunt, Nicola Jones, Monika Keelan, Agnes KleinErnst Kuipers, Raymond Lahaie, Des Leddin, Yves Levasseur, Miller MacSween, Serge Mayrand, James McHattie, Peter Rossos, David Schauer, Phil Sherman, Fiona Smail, Lesley Smith, Wendy Smith, Jean Spenard, Louise St Onge, Alan B.R. Thomson, Gervais Tougas, Noel William, Niek de Wit, Sander Veldhuyzen van Zanter

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


In patients with diseases known to be associated with Helicobacter pylori infection, such as peptic ulcer, treatment of the underlying infection is the standard of care. However, in most major consensus management guidelines, including those published in Canada, widespread testing for H pylori infection is not recommended. This practice is not encouraged because of insufficient evidence of cost-benefit in gastric cancer prevention, the potential for increases in antibiotic resistance and the controversial hypothesis of potential negative effects of eradication in certain clinical entities. For example, there is insufficient evidence to recommend against eradicating H pylori discovered in a patient with symptoms of gastroesophageal reflux disease. The management guidelines designed specifically in Canada should, therefore, continue to be applied, with H pylori diagnosed and treated in appropriately selected patients.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalCanadian Journal of Gastroenterology
Issue number1
StatePublished - 2002
Externally publishedYes


  • Helicobacter pylori
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology


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