Abstract
Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.
| Original language | English |
|---|---|
| Pages (from-to) | 1642-1651 |
| Number of pages | 10 |
| Journal | European Heart Journal |
| Volume | 35 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jul 1 2014 |
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Keywords
- Autonomic nervous system
- Cardiac function
- Electrical instability
- Genetics
- Risk stratification
- Sudden cardiac death
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Risk stratification for sudden cardiac death : Current status and challenges for the future. / Wellens, Hein J J; Schwartz, Peter J.; Lindemans, Fred W.; Buxton, Alfred E.; Goldberger, Jeffrey; Hohnloser, Stefan H.; Huikuri, Heikki V.; Kääb, Stefan; La Rovere, Maria Teresa; Malik, Marek; Myerburg, Robert J; Simoons, Maarten L.; Swedberg, Karl; Tijssen, Jan; Voors, Adriaan A.; Wilde, Arthur A.
In: European Heart Journal, Vol. 35, No. 25, 01.07.2014, p. 1642-1651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk stratification for sudden cardiac death
T2 - Current status and challenges for the future
AU - Wellens, Hein J J
AU - Schwartz, Peter J.
AU - Lindemans, Fred W.
AU - Buxton, Alfred E.
AU - Goldberger, Jeffrey
AU - Hohnloser, Stefan H.
AU - Huikuri, Heikki V.
AU - Kääb, Stefan
AU - La Rovere, Maria Teresa
AU - Malik, Marek
AU - Myerburg, Robert J
AU - Simoons, Maarten L.
AU - Swedberg, Karl
AU - Tijssen, Jan
AU - Voors, Adriaan A.
AU - Wilde, Arthur A.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.
AB - Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.
KW - Autonomic nervous system
KW - Cardiac function
KW - Electrical instability
KW - Genetics
KW - Risk stratification
KW - Sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=84903999617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903999617&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehu176
DO - 10.1093/eurheartj/ehu176
M3 - Article
C2 - 24801071
AN - SCOPUS:84903999617
VL - 35
SP - 1642
EP - 1651
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 25
ER -