Risk of preterm delivery and growth restriction in twins discordant for structural anomalies

Lorie M. Harper; Anthony O. Odibo; Kimberly A. Roehl; Ryan E. Longman; George A. MacOnes; Alison G. Cahill

doi:10.1016/j.ajog.2011.07.025

Risk of preterm delivery and growth restriction in twins discordant for structural anomalies

Lorie M. Harper, Anthony O. Odibo, Kimberly A. Roehl, Ryan E. Longman, George A. MacOnes, Alison G. Cahill

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.

Original language	English (US)
Pages (from-to)	70.e1-70.e5
Journal	American journal of obstetrics and gynecology
Volume	206
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2011.07.025
State	Published - Jan 2012
Externally published	Yes

Keywords

anomalies
intrauterine growth restriction
multiple gestation
preterm delivery

ASJC Scopus subject areas

Obstetrics and Gynecology

Access to Document

10.1016/j.ajog.2011.07.025

Fingerprint Dive into the research topics of 'Risk of preterm delivery and growth restriction in twins discordant for structural anomalies'. Together they form a unique fingerprint.

Cite this

@article{9eb595b32c834a369bc6b8e5e41139bc,

title = "Risk of preterm delivery and growth restriction in twins discordant for structural anomalies",

abstract = "We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.",

keywords = "anomalies, intrauterine growth restriction, multiple gestation, preterm delivery",

author = "Harper, {Lorie M.} and Odibo, {Anthony O.} and Roehl, {Kimberly A.} and Longman, {Ryan E.} and MacOnes, {George A.} and Cahill, {Alison G.}",

note = "Funding Information: L.M.H. is supported by a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( T32HD055172 ; principal investigator, G.A.M.) and by Grant no. UL1RR024992 from the National Institutes of Health/National Center for Research Resources (principal investigator, Bradley Evanoff, MD, MPH). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2012",

month = jan,

doi = "10.1016/j.ajog.2011.07.025",

language = "English (US)",

volume = "206",

pages = "70.e1--70.e5",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Risk of preterm delivery and growth restriction in twins discordant for structural anomalies

AU - Harper, Lorie M.

AU - Odibo, Anthony O.

AU - Roehl, Kimberly A.

AU - Longman, Ryan E.

AU - MacOnes, George A.

AU - Cahill, Alison G.

N1 - Funding Information: L.M.H. is supported by a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( T32HD055172 ; principal investigator, G.A.M.) and by Grant no. UL1RR024992 from the National Institutes of Health/National Center for Research Resources (principal investigator, Bradley Evanoff, MD, MPH). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2012/1

Y1 - 2012/1

N2 - We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.

AB - We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.

KW - anomalies

KW - intrauterine growth restriction

KW - multiple gestation

KW - preterm delivery

UR - http://www.scopus.com/inward/record.url?scp=84455191834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84455191834&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2011.07.025

DO - 10.1016/j.ajog.2011.07.025

M3 - Article

C2 - 21924394

AN - SCOPUS:84455191834

VL - 206

SP - 70.e1-70.e5

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -

Risk of preterm delivery and growth restriction in twins discordant for structural anomalies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this