Abstract
We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 206 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
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Keywords
- anomalies
- intrauterine growth restriction
- multiple gestation
- preterm delivery
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Risk of preterm delivery and growth restriction in twins discordant for structural anomalies. / Harper, Lorie M.; Odibo, Anthony O.; Roehl, Kimberly A.; Longman, Ryan E; MacOnes, George A.; Cahill, Alison G.
In: American Journal of Obstetrics and Gynecology, Vol. 206, No. 1, 01.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk of preterm delivery and growth restriction in twins discordant for structural anomalies
AU - Harper, Lorie M.
AU - Odibo, Anthony O.
AU - Roehl, Kimberly A.
AU - Longman, Ryan E
AU - MacOnes, George A.
AU - Cahill, Alison G.
PY - 2012/1
Y1 - 2012/1
N2 - We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.
AB - We sought to determine whether twin gestations with an anomalous fetus are at increased risk of preterm delivery or intrauterine growth restriction (IUGR) compared to twins with 2 normal fetuses. This was a retrospective cohort of twins undergoing ultrasound 15-22 weeks' gestation. Groups were defined by the presence of 1 twin with a major anomaly (discordant) or by twins with no major anomalies (normal). The primary outcomes were preterm delivery (<37 weeks) and IUGR (<10th percentile). Of 1977 twin pregnancies, 66 had a twin with a major anomaly. Preterm delivery occurred in 42 (63.6%) discordant twins, compared to 1271 (66.5%) normal twins (risk ratio, 1.0; 95% confidence interval, 0.81.2). IUGR was diagnosed in 15 (22.7%) normal co-twins, compared to 406 (21.3%) presenting twins in normal twins (risk ratio, 1.1; 95% confidence interval, 0.71.7). Twins discordant for major anomalies are not at increased risk of preterm delivery or IUGR compared to twins with no major anomalies.
KW - anomalies
KW - intrauterine growth restriction
KW - multiple gestation
KW - preterm delivery
UR - http://www.scopus.com/inward/record.url?scp=84455191834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84455191834&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2011.07.025
DO - 10.1016/j.ajog.2011.07.025
M3 - Article
C2 - 21924394
AN - SCOPUS:84455191834
VL - 206
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -