Risk factors of metabolic bone disease of prematurity

Supamit Ukarapong, Sunil Kumar Batlahally Venkatarayappa, Cristina Navarrete, Gary Berkovitz

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective To identify the factors that increase risk of metabolic bone disease of prematurity (MBD). Study design A retrospective case-control study of infants born between January 2013–April 2014 with gestation age < 30 weeks and birth weight < 1000 g. MBD was defined as serum alkaline phosphatase above 500 U/L and characteristic radiographic changes. Information was obtained on the presence of specific comorbidities. Results Of 76 infants evaluated, 40 met criteria for MBD. Median gestational age was 25 weeks in both groups (p = 0.512). Median birth weight of infants with MBD was significantly lower than that of controls (560 vs. 765 g, p < 0.01). Longer period of parenteral nutrition and dexamethasone use was observed in MBD group. Cholestasis was associated with the highest likelihood of MBD (OR 16.6, 95% CI 4.8–56.9). Seizures (OR 5.2, 95% CI 1.3–20.5) and the prolonged use of diuretics (OR 2.6, 95% CI 1.0–7.0) also significantly increased the likelihood of MBD. Only cholestasis remained significant (OR 9.6, 95% CI 2.1–45.3) after multiple regression analysis. Conclusion Cholestasis is a significant risk factor for the development of MBD. Our future studies will be directed towards determining the causal relationship between cholestasis and MBD.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalEarly Human Development
StatePublished - Sep 1 2017


  • Bone
  • Preterm infant
  • Risk factor and comorbidities

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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