Risk factors for inspiratory muscle weakness in chronic heart failure

Naomi Kondo Nakagawa, Mariana Abreu Diz, Tatiana Satie Kawauchi, Geisa Nascimento de Andrade, Iracema Ioco Kikuchi Umeda, Fernanda Murata Murakami, Janaina Proença Oliveira-Maul, Juliana Araújo Nascimento, Newton Nunes, Júlio Yoshio Takada, Antonio de Padua Mansur, Lawrence Patrick Cahalin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


BACKGROUND: Chronic heart failure is commonly associated with inspiratory muscle weakness. However, few studies have investigated the risk factors for inspiratory muscle weakness in individuals with chronic heart failure and systolic dysfunction (left-ventricular ejection fraction [LVEF] <40%). METHODS: Seventy subjects were recruited in a cardiac center. We assessed clinical parameters, smoking history, peripheral muscle strength, pulmonary function, echocardio-graphic variables, and brain natriuretic peptide. The subjects were classified with inspiratory muscle weakness when the maximum inspiratory pressure was <70% of predicted values. RESULTS: Thirty-six subjects (51%) had inspiratory muscle weakness. The subjects with inspira-tory muscle weakness and the subjects with no inspiratory muscle weakness were similar in age, sex, body mass index, medication use, and physical activity. However, the subjects with inspiratory muscle weakness had lower LVEF (P ± .003), systolic blood pressure (P ± .01), diastolic blood pressure (P ± .042), quadriceps muscle strength (P ± .02), lung function (P ± .035), increased brain natriuretic peptide (P ± .02), smoking history (P ± .01), and pulmonary hypertension incidence (P ± .03). Multivariate logistic regression analysis found a lower LVEF, increased smoking history, and lower systolic blood pressure as significant independent predictors for inspiratory muscle weakness. CONCLUSIONS: The combination of lower LVEF, lower systolic blood pressure, and smoking history predicted inspiratory muscle weakness. Patients with suspected inspiratory muscle weakness should be examined and, if inspiratory muscle weakness exists, then inspiratory muscle training should be provided. Reducing inspiratory muscle weakness has the potential to improve many of the deleterious effects of chronic heart failure.

Original languageEnglish (US)
Pages (from-to)507-516
Number of pages10
JournalRespiratory care
Issue number4
StatePublished - Apr 1 2020


  • Cardiovascular diseases
  • Respi-ratory ratory function tests
  • Respiratory structure and function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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