Risk factors for HIV-1 seroconversion among injection drug users

A case- control study

D. D. Chitwood, D. K. Griffin, M. Comerford, John Page, E. J. Trapido, S. Lai, Clyde B McCoy

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objectives. A nested case-control study was conducted in Miami, Fla, to determine risk factors associated with human immunodeficiency virus type 1 (HIV-1) seroconversion among injection drug users. Methods. The study identified 21 incident cases of HIV-1 infection and 76 unmatched controls from two longitudinal cohorts of injection drug users. One cohort consisted of individuals who originally had been recruited from treatment centers; a second cohort was recruited from the 'street.' Logistic regression analyses that adjusted for age, gender, and race were performed. Results. The final model determined that the primary independent risk factor that best explained the risk for seroconversion was sharing injection equipment in the year prior to conversion; a marginal risk factor was presence of sexually transmitted disease during this same period. Conclusions. Both an injection component and a sexual component play a role in seroconversion among injection drug users, although the injection component is much stronger.

Original languageEnglish
Pages (from-to)1538-1542
Number of pages5
JournalAmerican Journal of Public Health
Volume85
Issue number11
StatePublished - Jan 1 1995

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Drug Users
HIV-1
Case-Control Studies
Injections
Virus Diseases
Sexually Transmitted Diseases
Seroconversion
Logistic Models
Regression Analysis
Equipment and Supplies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Chitwood, D. D., Griffin, D. K., Comerford, M., Page, J., Trapido, E. J., Lai, S., & McCoy, C. B. (1995). Risk factors for HIV-1 seroconversion among injection drug users: A case- control study. American Journal of Public Health, 85(11), 1538-1542.

Risk factors for HIV-1 seroconversion among injection drug users : A case- control study. / Chitwood, D. D.; Griffin, D. K.; Comerford, M.; Page, John; Trapido, E. J.; Lai, S.; McCoy, Clyde B.

In: American Journal of Public Health, Vol. 85, No. 11, 01.01.1995, p. 1538-1542.

Research output: Contribution to journalArticle

Chitwood, DD, Griffin, DK, Comerford, M, Page, J, Trapido, EJ, Lai, S & McCoy, CB 1995, 'Risk factors for HIV-1 seroconversion among injection drug users: A case- control study', American Journal of Public Health, vol. 85, no. 11, pp. 1538-1542.
Chitwood DD, Griffin DK, Comerford M, Page J, Trapido EJ, Lai S et al. Risk factors for HIV-1 seroconversion among injection drug users: A case- control study. American Journal of Public Health. 1995 Jan 1;85(11):1538-1542.
Chitwood, D. D. ; Griffin, D. K. ; Comerford, M. ; Page, John ; Trapido, E. J. ; Lai, S. ; McCoy, Clyde B. / Risk factors for HIV-1 seroconversion among injection drug users : A case- control study. In: American Journal of Public Health. 1995 ; Vol. 85, No. 11. pp. 1538-1542.
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