Risk factors for early recurrence after ischemic stroke: The role of stroke syndrome and subtype

Joan T. Moroney, Emilia Bagiella, Myunghee C. Paik, Ralph L. Sacco, David W. Desmond

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Background and Purpose - Information regarding risk factors for early recurrence is limited. Our aim was to identify the clinical predictors of early recurrence after ischemic stroke. Methods - We prospectively examined 297 patients (mean age, 72.0±8.4 years) hospitalized with ischemic stroke to identify recurrent strokes occurring within 90 days of the index stroke. Survival free of recurrence was estimated using Kaplan-Meier analysis stratified by demographic variables; vascular risk factors; stroke syndrome, subtype, vascular territory, and severity; scores on the Barthel Index and Mini-Mental State Examination during hospitalization; blood pressure on admission; and selected laboratory data. We estimated the relative risk (RR) of early recurrence associated with those variables using proportional hazards analysis. Results - We identified 22 recurrent events in the first 90 days after the index stroke, resulting in an early stroke recurrence rate of 7.4%, and death occurred immediately after recurrence in 6 of the 22 patients. A major hemispheric stroke syndrome (RR=2.9; 95% confidence interval [CI]=1.2 to 7.1), atherothrombotic stroke mechanism (RR=3.3; CI=1.3 to 8.3), and atrial fibrillation (RR=2.2; CI=0.8 to 6.1) were independent predictors of early recurrence, after adjustment for demographic variables. Conclusions - Early recurrence was frequent and resulted in increased mortality. Attention to the clinical features of the index stroke, including the presenting syndrome and the ischemic mechanism, and the recognition of atrial fibrillation may help in the selection of patients for the initiation of targeted interventions to prevent early recurrence and subsequent mortality.

Original languageEnglish (US)
Pages (from-to)2118-2124
Number of pages7
Issue number10
StatePublished - Oct 1998
Externally publishedYes


  • Mortality
  • Risk factors
  • Stroke outcome
  • Stroke, ischemic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


Dive into the research topics of 'Risk factors for early recurrence after ischemic stroke: The role of stroke syndrome and subtype'. Together they form a unique fingerprint.

Cite this