Risk factors for corneal infiltrates with continuous wear of contact lenses

Robin L. Chalmers, John J. McNally, Oliver D. Schein, Joanne Katz, James M. Tielsch, Eduardo C Alfonso, Mark Bullimore, Denis O'Day, Joseph Shovlin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

PURPOSE. To describe the factors associated with symptomatic corneal infiltrates in a postmarket surveillance study of continuous wear contact lenses. METHODS. Patients intending to wear lotrafilcon A lenses continuously for 30 days and nights were registered in a 1-year study at 131 clinical sites. A self-administered questionnaire was used to gather demographic and other data at baseline. The severity of the incidence of corneal infiltrative events during the year-long study was graded by an independent adjudication committee. RESULTS. Of 6245 lens wearers, 163 were reported to have symptomatic corneal infiltrative events (2.6%). In 159 wearers, the infiltrates were judged to be lens-related (2.5%). Age ≤25 years and >50 years was significantly associated with the development of corneal infiltrates (≤25 years OR = 1.75, 95% CI = 1.24-2.48 and >50 years OR = 2.04, 95% CI = 1.40-2.98). Ametropia of ≥5.00 D was significantly associated with corneal infiltrates (OR = 1.60, 95% CI = 1.08-2.37). Study participants who typically wore lenses for >21 consecutive days and nights were significantly less likely to have infiltrates than those who wore lenses for fewer consecutive days and nights (OR = 0.43, 95% CI = 0.24-0.75). Smoking concurrent with contact lens wear was weakly associated with corneal infiltrates (OR = 1.47, CI = 0.99-2.18). CONCLUSIONS. Patient age, degree of refractive error, and failure to achieve the intended wearing schedule were associated with development of symptomatic corneal infiltrative events.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalOptometry and Vision Science
Volume84
Issue number7
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Fingerprint

Contact Lenses
Lenses
Refractive Errors
Appointments and Schedules
Smoking
Demography
Incidence

Keywords

  • Corneal infiltrates
  • Postmarket surveillance
  • Risk factors
  • Silicone hydrogel lenses

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chalmers, R. L., McNally, J. J., Schein, O. D., Katz, J., Tielsch, J. M., Alfonso, E. C., ... Shovlin, J. (2007). Risk factors for corneal infiltrates with continuous wear of contact lenses. Optometry and Vision Science, 84(7), 573-579. https://doi.org/10.1097/OPX.0b013e3180dc9a12

Risk factors for corneal infiltrates with continuous wear of contact lenses. / Chalmers, Robin L.; McNally, John J.; Schein, Oliver D.; Katz, Joanne; Tielsch, James M.; Alfonso, Eduardo C; Bullimore, Mark; O'Day, Denis; Shovlin, Joseph.

In: Optometry and Vision Science, Vol. 84, No. 7, 01.07.2007, p. 573-579.

Research output: Contribution to journalArticle

Chalmers, RL, McNally, JJ, Schein, OD, Katz, J, Tielsch, JM, Alfonso, EC, Bullimore, M, O'Day, D & Shovlin, J 2007, 'Risk factors for corneal infiltrates with continuous wear of contact lenses', Optometry and Vision Science, vol. 84, no. 7, pp. 573-579. https://doi.org/10.1097/OPX.0b013e3180dc9a12
Chalmers, Robin L. ; McNally, John J. ; Schein, Oliver D. ; Katz, Joanne ; Tielsch, James M. ; Alfonso, Eduardo C ; Bullimore, Mark ; O'Day, Denis ; Shovlin, Joseph. / Risk factors for corneal infiltrates with continuous wear of contact lenses. In: Optometry and Vision Science. 2007 ; Vol. 84, No. 7. pp. 573-579.
@article{6e249059d4a04a14b1145fcd1761f1dd,
title = "Risk factors for corneal infiltrates with continuous wear of contact lenses",
abstract = "PURPOSE. To describe the factors associated with symptomatic corneal infiltrates in a postmarket surveillance study of continuous wear contact lenses. METHODS. Patients intending to wear lotrafilcon A lenses continuously for 30 days and nights were registered in a 1-year study at 131 clinical sites. A self-administered questionnaire was used to gather demographic and other data at baseline. The severity of the incidence of corneal infiltrative events during the year-long study was graded by an independent adjudication committee. RESULTS. Of 6245 lens wearers, 163 were reported to have symptomatic corneal infiltrative events (2.6{\%}). In 159 wearers, the infiltrates were judged to be lens-related (2.5{\%}). Age ≤25 years and >50 years was significantly associated with the development of corneal infiltrates (≤25 years OR = 1.75, 95{\%} CI = 1.24-2.48 and >50 years OR = 2.04, 95{\%} CI = 1.40-2.98). Ametropia of ≥5.00 D was significantly associated with corneal infiltrates (OR = 1.60, 95{\%} CI = 1.08-2.37). Study participants who typically wore lenses for >21 consecutive days and nights were significantly less likely to have infiltrates than those who wore lenses for fewer consecutive days and nights (OR = 0.43, 95{\%} CI = 0.24-0.75). Smoking concurrent with contact lens wear was weakly associated with corneal infiltrates (OR = 1.47, CI = 0.99-2.18). CONCLUSIONS. Patient age, degree of refractive error, and failure to achieve the intended wearing schedule were associated with development of symptomatic corneal infiltrative events.",
keywords = "Corneal infiltrates, Postmarket surveillance, Risk factors, Silicone hydrogel lenses",
author = "Chalmers, {Robin L.} and McNally, {John J.} and Schein, {Oliver D.} and Joanne Katz and Tielsch, {James M.} and Alfonso, {Eduardo C} and Mark Bullimore and Denis O'Day and Joseph Shovlin",
year = "2007",
month = "7",
day = "1",
doi = "10.1097/OPX.0b013e3180dc9a12",
language = "English",
volume = "84",
pages = "573--579",
journal = "Optometry and Vision Science",
issn = "1040-5488",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Risk factors for corneal infiltrates with continuous wear of contact lenses

AU - Chalmers, Robin L.

AU - McNally, John J.

AU - Schein, Oliver D.

AU - Katz, Joanne

AU - Tielsch, James M.

AU - Alfonso, Eduardo C

AU - Bullimore, Mark

AU - O'Day, Denis

AU - Shovlin, Joseph

PY - 2007/7/1

Y1 - 2007/7/1

N2 - PURPOSE. To describe the factors associated with symptomatic corneal infiltrates in a postmarket surveillance study of continuous wear contact lenses. METHODS. Patients intending to wear lotrafilcon A lenses continuously for 30 days and nights were registered in a 1-year study at 131 clinical sites. A self-administered questionnaire was used to gather demographic and other data at baseline. The severity of the incidence of corneal infiltrative events during the year-long study was graded by an independent adjudication committee. RESULTS. Of 6245 lens wearers, 163 were reported to have symptomatic corneal infiltrative events (2.6%). In 159 wearers, the infiltrates were judged to be lens-related (2.5%). Age ≤25 years and >50 years was significantly associated with the development of corneal infiltrates (≤25 years OR = 1.75, 95% CI = 1.24-2.48 and >50 years OR = 2.04, 95% CI = 1.40-2.98). Ametropia of ≥5.00 D was significantly associated with corneal infiltrates (OR = 1.60, 95% CI = 1.08-2.37). Study participants who typically wore lenses for >21 consecutive days and nights were significantly less likely to have infiltrates than those who wore lenses for fewer consecutive days and nights (OR = 0.43, 95% CI = 0.24-0.75). Smoking concurrent with contact lens wear was weakly associated with corneal infiltrates (OR = 1.47, CI = 0.99-2.18). CONCLUSIONS. Patient age, degree of refractive error, and failure to achieve the intended wearing schedule were associated with development of symptomatic corneal infiltrative events.

AB - PURPOSE. To describe the factors associated with symptomatic corneal infiltrates in a postmarket surveillance study of continuous wear contact lenses. METHODS. Patients intending to wear lotrafilcon A lenses continuously for 30 days and nights were registered in a 1-year study at 131 clinical sites. A self-administered questionnaire was used to gather demographic and other data at baseline. The severity of the incidence of corneal infiltrative events during the year-long study was graded by an independent adjudication committee. RESULTS. Of 6245 lens wearers, 163 were reported to have symptomatic corneal infiltrative events (2.6%). In 159 wearers, the infiltrates were judged to be lens-related (2.5%). Age ≤25 years and >50 years was significantly associated with the development of corneal infiltrates (≤25 years OR = 1.75, 95% CI = 1.24-2.48 and >50 years OR = 2.04, 95% CI = 1.40-2.98). Ametropia of ≥5.00 D was significantly associated with corneal infiltrates (OR = 1.60, 95% CI = 1.08-2.37). Study participants who typically wore lenses for >21 consecutive days and nights were significantly less likely to have infiltrates than those who wore lenses for fewer consecutive days and nights (OR = 0.43, 95% CI = 0.24-0.75). Smoking concurrent with contact lens wear was weakly associated with corneal infiltrates (OR = 1.47, CI = 0.99-2.18). CONCLUSIONS. Patient age, degree of refractive error, and failure to achieve the intended wearing schedule were associated with development of symptomatic corneal infiltrative events.

KW - Corneal infiltrates

KW - Postmarket surveillance

KW - Risk factors

KW - Silicone hydrogel lenses

UR - http://www.scopus.com/inward/record.url?scp=34447503484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447503484&partnerID=8YFLogxK

U2 - 10.1097/OPX.0b013e3180dc9a12

DO - 10.1097/OPX.0b013e3180dc9a12

M3 - Article

C2 - 17632304

AN - SCOPUS:34447503484

VL - 84

SP - 573

EP - 579

JO - Optometry and Vision Science

JF - Optometry and Vision Science

SN - 1040-5488

IS - 7

ER -