Risk factors for corneal infiltrates with continuous wear of contact lenses

Robin L. Chalmers, John J. McNally, Oliver D. Schein, Joanne Katz, James M. Tielsch, Eduardo Alfonso, Mark Bullimore, Denis O'Day, Joseph Shovlin

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

PURPOSE. To describe the factors associated with symptomatic corneal infiltrates in a postmarket surveillance study of continuous wear contact lenses. METHODS. Patients intending to wear lotrafilcon A lenses continuously for 30 days and nights were registered in a 1-year study at 131 clinical sites. A self-administered questionnaire was used to gather demographic and other data at baseline. The severity of the incidence of corneal infiltrative events during the year-long study was graded by an independent adjudication committee. RESULTS. Of 6245 lens wearers, 163 were reported to have symptomatic corneal infiltrative events (2.6%). In 159 wearers, the infiltrates were judged to be lens-related (2.5%). Age ≤25 years and >50 years was significantly associated with the development of corneal infiltrates (≤25 years OR = 1.75, 95% CI = 1.24-2.48 and >50 years OR = 2.04, 95% CI = 1.40-2.98). Ametropia of ≥5.00 D was significantly associated with corneal infiltrates (OR = 1.60, 95% CI = 1.08-2.37). Study participants who typically wore lenses for >21 consecutive days and nights were significantly less likely to have infiltrates than those who wore lenses for fewer consecutive days and nights (OR = 0.43, 95% CI = 0.24-0.75). Smoking concurrent with contact lens wear was weakly associated with corneal infiltrates (OR = 1.47, CI = 0.99-2.18). CONCLUSIONS. Patient age, degree of refractive error, and failure to achieve the intended wearing schedule were associated with development of symptomatic corneal infiltrative events.

Original languageEnglish (US)
Pages (from-to)573-579
Number of pages7
JournalOptometry and Vision Science
Volume84
Issue number7
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Keywords

  • Corneal infiltrates
  • Postmarket surveillance
  • Risk factors
  • Silicone hydrogel lenses

ASJC Scopus subject areas

  • Ophthalmology

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    Chalmers, R. L., McNally, J. J., Schein, O. D., Katz, J., Tielsch, J. M., Alfonso, E., Bullimore, M., O'Day, D., & Shovlin, J. (2007). Risk factors for corneal infiltrates with continuous wear of contact lenses. Optometry and Vision Science, 84(7), 573-579. https://doi.org/10.1097/OPX.0b013e3180dc9a12