Abstract
We report our experience with 7 consecutive patients with Parkinson's disease (PD) who received rimantadine (the α-methyl derivative of amantadine) in substitution of amantadine due to peripheral side effects (lower limb edema, livedo reticularis). Mean age was 67.3 ± 5.9 years, the mean disease duration was 13 ± 6.3 years, and mean Hoehn and Yahr stage was 2.2 ± 0.4. A total of 3 patients experienced marked improvement of edema, and 1 patient experienced marked improvement of livedo reticularis. Only 1 of the 7 patients reported significant loss of motor benefit when amantadine was replaced with rimantadine. Our results demonstrate that rimantadine may be considered as an alternative to amantadine in patients experiencing amantadine-induced peripheral side effects.
Original language | English (US) |
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Pages (from-to) | 873-877 |
Number of pages | 5 |
Journal | Movement Disorders |
Volume | 20 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2005 |
Keywords
- Amantadine
- Edema
- Parkinson's disease
- Rimantadine
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)