Rimantadine in Parkinson's disease patients experiencing peripheral adverse effects from amantadine: Report of a case series

Carlos Singer; Spiridon Papapetropoulos; Manuel A. Gonzalez; Eugene L. Roberts; Abraham Lieberman

doi:10.1002/mds.20471

Rimantadine in Parkinson's disease patients experiencing peripheral adverse effects from amantadine: Report of a case series

Carlos Singer, Spiridon Papapetropoulos, Manuel A. Gonzalez, Eugene L. Roberts, Abraham Lieberman

Neurology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We report our experience with 7 consecutive patients with Parkinson's disease (PD) who received rimantadine (the α-methyl derivative of amantadine) in substitution of amantadine due to peripheral side effects (lower limb edema, livedo reticularis). Mean age was 67.3 ± 5.9 years, the mean disease duration was 13 ± 6.3 years, and mean Hoehn and Yahr stage was 2.2 ± 0.4. A total of 3 patients experienced marked improvement of edema, and 1 patient experienced marked improvement of livedo reticularis. Only 1 of the 7 patients reported significant loss of motor benefit when amantadine was replaced with rimantadine. Our results demonstrate that rimantadine may be considered as an alternative to amantadine in patients experiencing amantadine-induced peripheral side effects.

Original language	English (US)
Pages (from-to)	873-877
Number of pages	5
Journal	Movement Disorders
Volume	20
Issue number	7
DOIs	https://doi.org/10.1002/mds.20471
State	Published - Jul 1 2005

Keywords

Amantadine
Edema
Parkinson's disease
Rimantadine

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.20471

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abstract = "We report our experience with 7 consecutive patients with Parkinson's disease (PD) who received rimantadine (the α-methyl derivative of amantadine) in substitution of amantadine due to peripheral side effects (lower limb edema, livedo reticularis). Mean age was 67.3 ± 5.9 years, the mean disease duration was 13 ± 6.3 years, and mean Hoehn and Yahr stage was 2.2 ± 0.4. A total of 3 patients experienced marked improvement of edema, and 1 patient experienced marked improvement of livedo reticularis. Only 1 of the 7 patients reported significant loss of motor benefit when amantadine was replaced with rimantadine. Our results demonstrate that rimantadine may be considered as an alternative to amantadine in patients experiencing amantadine-induced peripheral side effects.",

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