Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial.

Michael G. Fehlings, Jefferson R. Wilson, Ralph F. Frankowski, Elizabeth G. Toups, Bizhan Aarabi, James S. Harrop, Christopher I. Shaffrey, Susan J. Harkema, James D. Guest, Charles H. Tator, Keith D. Burau, Michele W. Johnson, Robert G. Grossman

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

In the immediate period after traumatic spinal cord injury (SCI) a variety of secondary injury mechanisms combine to gradually expand the initial lesion size, potentially leading to diminished neurological outcomes at long-term follow-up. Riluzole, a benzothiazole drug, which has neuroprotective properties based on sodium channel blockade and mitigation of glutamatergic toxicity, is currently an approved drug that attenuates the extent of neuronal degeneration in patients with amyotrophic lateral sclerosis. Moreover, several preclinical SCI studies have associated riluzole administration with improved functional outcomes and increased neural tissue preservation. Based on these findings, riluzole has attracted considerable interest as a potential neuroprotective drug for the treatment of SCI. Currently, a Phase I trial evaluating the safety and pharmacokinetic profile of riluzole in human SCI patients is being conducted by the North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury. The current review summarizes the existing preclinical and clinical literature on riluzole, provides a detailed description of the Phase I trial, and suggests potential opportunities for future investigation. Clinical trial registration no.: NCT00876889.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalJournal of neurosurgery. Spine
Volume17
Issue number1 Suppl
DOIs
StatePublished - Sep 2012

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology

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    Fehlings, M. G., Wilson, J. R., Frankowski, R. F., Toups, E. G., Aarabi, B., Harrop, J. S., Shaffrey, C. I., Harkema, S. J., Guest, J. D., Tator, C. H., Burau, K. D., Johnson, M. W., & Grossman, R. G. (2012). Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial. Journal of neurosurgery. Spine, 17(1 Suppl), 151-156. https://doi.org/10.3171/2012.4.aospine1259