RIG-1 receptor expression in the pathology of Alzheimer's disease

Juan P. De Rivero Vaccari, Frank J. Brand, Christina Sedaghat, Deborah C. Mash, W. D. Dietrich, Robert W. Keane

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Neuroinflammation plays a critical role in the pathogenesis of Alzheimer's disease (AD) and involves activation of the innate immune response via recognition of diverse stimuli by pattern recognition receptors (PRRs). The inflammatory inducers and precise innate signaling pathway contributing to AD pathology remain largely undefined.Results: In the present study we analyzed expression levels of innate immune proteins in temporal and occipital cortices from preclinical (no cognitive impairment, NCI, N = 22) to mild cognitive impairment (MCI, N = 20) associated with AD pathology (N = 20) and AD patients (N = 23). We found that retinoic acid-inducible gene-I (RIG-1) is significantly elevated in the temporal cortex and plasma in patients with MCI. In addition, primary human astrocytes stimulated with the RIG-1 ligand 5'ppp RNA showed increased expression of amyloid precursor protein (APP) and amyloid-β (Aβ), supporting the idea that RIG-1 is involved in the pathology of MCI associated with early progression to AD.Conclusion: These findings suggest that RIG-1 may play a critical role in incipient AD.

Original languageEnglish (US)
Article number67
JournalJournal of Neuroinflammation
Volume11
DOIs
StatePublished - Apr 2 2014

Keywords

  • Alzheimer's disease
  • Inflammation
  • Innate immunity
  • Mild cognitive impairment
  • Rig signaling
  • RLR

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology
  • Neuroscience(all)
  • Medicine(all)

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