Human leukemic lymphoblasts exposed to Velban show prominent proteinaceous crystals and large complexes of ribosomes (which are arranged in clusters and helices) in association with fine granular, electron dense material. This granular material shows relatively greater electron density than the crystals and lacks the prominent linearity of the crystals. In some cross sections tubular profiles are seen interspersed between the granular material and the ribosomes. It is suggested that the ribosomes are involved in the synthesis of the electron-dense material which is subsequently organized into the prominent crystals.
ASJC Scopus subject areas
- Molecular Biology