Abstract
Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine daily rhythms in activity levels, mood, alertness, and performance. Seven healthy subjects were given a cumulative activity score reflecting propensity toward morningness or eveningness. Subjects underwent CRH challenge testing during the morning and evening hours of different days. Baseline plasma ACTH and cortisol concentrations were higher in the morning than in the evening and lower values were associated with lower activity scores (i.e., greater morningness). No trends were apparent between activity score and net hormone response or percent change in hormone concentration.
Original language | English |
---|---|
Pages (from-to) | 101-106 |
Number of pages | 6 |
Journal | Neurobiology of Aging |
Volume | 14 |
Issue number | 1 |
State | Published - Dec 1 1993 |
Externally published | Yes |
Fingerprint
Keywords
- ACTH
- Adrenocorticotropic hormone
- Aging
- Biological rhythms
- Circadian rhythms
- Corticotropin-releasing hormone
- Cortisol
- CRH challenge
- Eveningness
- Morningness
- Rhythmicity
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects. / Blazer, Dan G.; Malmrose, Lynda C.; Wallsten, Sharon M.; Nemeroff, Charles; Reed, Deborah A.; Ritchie, James C.; Tyrey, Mary E.
In: Neurobiology of Aging, Vol. 14, No. 1, 01.12.1993, p. 101-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects
AU - Blazer, Dan G.
AU - Malmrose, Lynda C.
AU - Wallsten, Sharon M.
AU - Nemeroff, Charles
AU - Reed, Deborah A.
AU - Ritchie, James C.
AU - Tyrey, Mary E.
PY - 1993/12/1
Y1 - 1993/12/1
N2 - Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine daily rhythms in activity levels, mood, alertness, and performance. Seven healthy subjects were given a cumulative activity score reflecting propensity toward morningness or eveningness. Subjects underwent CRH challenge testing during the morning and evening hours of different days. Baseline plasma ACTH and cortisol concentrations were higher in the morning than in the evening and lower values were associated with lower activity scores (i.e., greater morningness). No trends were apparent between activity score and net hormone response or percent change in hormone concentration.
AB - Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine daily rhythms in activity levels, mood, alertness, and performance. Seven healthy subjects were given a cumulative activity score reflecting propensity toward morningness or eveningness. Subjects underwent CRH challenge testing during the morning and evening hours of different days. Baseline plasma ACTH and cortisol concentrations were higher in the morning than in the evening and lower values were associated with lower activity scores (i.e., greater morningness). No trends were apparent between activity score and net hormone response or percent change in hormone concentration.
KW - ACTH
KW - Adrenocorticotropic hormone
KW - Aging
KW - Biological rhythms
KW - Circadian rhythms
KW - Corticotropin-releasing hormone
KW - Cortisol
KW - CRH challenge
KW - Eveningness
KW - Morningness
KW - Rhythmicity
UR - http://www.scopus.com/inward/record.url?scp=0027410045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027410045&partnerID=8YFLogxK
M3 - Article
C2 - 8383810
AN - SCOPUS:0027410045
VL - 14
SP - 101
EP - 106
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -