Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

Samuel D. Bernal, Theodore J. Lampidis, Ian C. Summerhayes, Lan Bo Chen

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

Original languageEnglish (US)
Pages (from-to)1117-1119
Number of pages3
JournalScience
Volume218
Issue number4577
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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