Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

Samuel D. Bernal; Theodore J. Lampidis; Ian C. Summerhayes; Lan Bo Chen

doi:10.1126/science.7146897

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

Samuel D. Bernal, Theodore J. Lampidis, Ian C. Summerhayes, Lan Bo Chen

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

Original language	English (US)
Pages (from-to)	1117-1119
Number of pages	3
Journal	Science
Volume	218
Issue number	4577
DOIs	https://doi.org/10.1126/science.7146897
State	Published - Jan 1 1982
Externally published	Yes

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title = "Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro",

abstract = "Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.",

author = "Bernal, {Samuel D.} and Lampidis, {Theodore J.} and Summerhayes, {Ian C.} and Chen, {Lan Bo}",

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AU - Lampidis, Theodore J.

AU - Summerhayes, Ian C.

AU - Chen, Lan Bo

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N2 - Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

AB - Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

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