Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

S. D. Bernal, Theodore Lampidis, I. C. Summerhayes, L. B. Chen

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

Original languageEnglish
Pages (from-to)1117-1119
Number of pages3
JournalScience
Volume218
Issue number4577
StatePublished - Dec 1 1982
Externally publishedYes

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Rhodamine 123
Carcinoma
Dye Lasers
Cytosine
Growth
Methotrexate
Epithelial Cells
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Bernal, S. D., Lampidis, T., Summerhayes, I. C., & Chen, L. B. (1982). Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Science, 218(4577), 1117-1119.

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. / Bernal, S. D.; Lampidis, Theodore; Summerhayes, I. C.; Chen, L. B.

In: Science, Vol. 218, No. 4577, 01.12.1982, p. 1117-1119.

Research output: Contribution to journalArticle

Bernal, SD, Lampidis, T, Summerhayes, IC & Chen, LB 1982, 'Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro', Science, vol. 218, no. 4577, pp. 1117-1119.
Bernal SD, Lampidis T, Summerhayes IC, Chen LB. Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Science. 1982 Dec 1;218(4577):1117-1119.
Bernal, S. D. ; Lampidis, Theodore ; Summerhayes, I. C. ; Chen, L. B. / Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. In: Science. 1982 ; Vol. 218, No. 4577. pp. 1117-1119.
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