Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

Samuel D. Bernal; Theodore J. Lampidis; Ian C. Summerhayes; Lan Bo Chen

doi:10.1126/science.7146897

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

Samuel D. Bernal, Theodore J. Lampidis, Ian C. Summerhayes, Lan Bo Chen

Research output: Contribution to journal › Article

160 Scopus citations

Abstract

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

Original language	English (US)
Pages (from-to)	1117-1119
Number of pages	3
Journal	Science
Volume	218
Issue number	4577
DOIs	https://doi.org/10.1126/science.7146897
State	Published - Jan 1 1982
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.7146897

Fingerprint Dive into the research topics of 'Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro'. Together they form a unique fingerprint.

Cite this

Bernal, S. D., Lampidis, T. J., Summerhayes, I. C., & Chen, L. B. (1982). Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Science, 218(4577), 1117-1119. https://doi.org/10.1126/science.7146897

@article{e8ac2ef1208b4445959a132b7147f972,

title = "Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro",

abstract = "Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.",

author = "Bernal, {Samuel D.} and Lampidis, {Theodore J.} and Summerhayes, {Ian C.} and Chen, {Lan Bo}",

year = "1982",

month = jan,

day = "1",

doi = "10.1126/science.7146897",

language = "English (US)",

volume = "218",

pages = "1117--1119",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4577",

}

TY - JOUR

T1 - Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

AU - Bernal, Samuel D.

AU - Lampidis, Theodore J.

AU - Summerhayes, Ian C.

AU - Chen, Lan Bo

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

AB - Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.

UR - http://www.scopus.com/inward/record.url?scp=0020428221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020428221&partnerID=8YFLogxK

U2 - 10.1126/science.7146897

DO - 10.1126/science.7146897

M3 - Article

C2 - 7146897

AN - SCOPUS:0020428221

VL - 218

SP - 1117

EP - 1119

JO - Science

JF - Science

SN - 0036-8075

IS - 4577

ER -