RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy

Irene Litosch

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα GTP can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G q efficacy.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalBiochemical and biophysical research communications
Volume415
Issue number2
DOIs
StatePublished - Nov 18 2011

Keywords

  • G proteins
  • GPCRs
  • GTPases
  • Phosphatidic acid
  • Phospholipase C-β
  • Phospholipase D
  • RhoA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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