Abstract
Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα GTP can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G q efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 215-219 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 415 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 18 2011 |
| Externally published | Yes |
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Keywords
- G proteins
- GPCRs
- GTPases
- Phosphatidic acid
- Phospholipase C-β
- Phospholipase D
- RhoA
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Molecular Biology
Cite this
RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy. / Litosch, Irene.
In: Biochemical and Biophysical Research Communications, Vol. 415, No. 2, 18.11.2011, p. 215-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy
AU - Litosch, Irene
PY - 2011/11/18
Y1 - 2011/11/18
N2 - Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα GTP can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G q efficacy.
AB - Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα GTP can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G q efficacy.
KW - G proteins
KW - GPCRs
KW - GTPases
KW - Phosphatidic acid
KW - Phospholipase C-β
KW - Phospholipase D
KW - RhoA
UR - http://www.scopus.com/inward/record.url?scp=84855865226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855865226&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2011.10.063
DO - 10.1016/j.bbrc.2011.10.063
M3 - Article
C2 - 22033406
AN - SCOPUS:84855865226
VL - 415
SP - 215
EP - 219
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -