Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Mitogenic growth factor- and integrin-dependent signaling pathways cooperate to control the proliferation of nontransformed cells. As integral mediators of these networks, the Rho family of GTPases play a pivotal role in G1 cell cycle progression, primarily through regulation of cyclin D1 expression, as well as the levels of the cyclin-dependent kinase inhibitors p21 cip1 and p27kip1. Such dual control of both the critical positive and negative regulators of Gl progression make the Rho GTPases prime candidates to target the autonomous proliferation which typifies cancer cells. Cyclin D1 has been identified as an important oncogene and the cdk inhibitors as tumor suppressors in human breast carcinogenesis. Evidence pointing to the potential role of Rho-dependent pathways and their interaction with oncogenic Ras in contributing to such cell cycle abnormalities that characterize human breast cancer is also presented.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalBreast Cancer Research and Treatment
Volume84
Issue number1
DOIs
StatePublished - Mar 1 2004

Fingerprint

rho GTP-Binding Proteins
Cyclin D1
Transducers
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p21
Oncogenes
Integrins
Neoplasms
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Breast
Cell Proliferation
Breast Neoplasms

Keywords

  • Adhesion
  • Cdc42
  • Extracellular matrix
  • Growth factors
  • Integrins
  • Rac

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation. / Welsh, Catherine.

In: Breast Cancer Research and Treatment, Vol. 84, No. 1, 01.03.2004, p. 33-42.

Research output: Contribution to journalArticle

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