Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation

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57 Scopus citations


Mitogenic growth factor- and integrin-dependent signaling pathways cooperate to control the proliferation of nontransformed cells. As integral mediators of these networks, the Rho family of GTPases play a pivotal role in G1 cell cycle progression, primarily through regulation of cyclin D1 expression, as well as the levels of the cyclin-dependent kinase inhibitors p21 cip1 and p27kip1. Such dual control of both the critical positive and negative regulators of Gl progression make the Rho GTPases prime candidates to target the autonomous proliferation which typifies cancer cells. Cyclin D1 has been identified as an important oncogene and the cdk inhibitors as tumor suppressors in human breast carcinogenesis. Evidence pointing to the potential role of Rho-dependent pathways and their interaction with oncogenic Ras in contributing to such cell cycle abnormalities that characterize human breast cancer is also presented.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalBreast cancer research and treatment
Issue number1
StatePublished - Mar 2004


  • Adhesion
  • Cdc42
  • Extracellular matrix
  • Growth factors
  • Integrins
  • Rac

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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