Rhinosinusitis in the pediatric patient with cystic fibrosis

Christopher Fundakowski, Rosemary Ojo, Ramzi T Younis

Research output: Chapter in Book/Report/Conference proceedingChapter


Cystic fibrosis (CF) is a common autosomal recessive genetic disorder where a deletion mutation and subsequent downstream alteration in transmembrane regulator proteins results in increased mucus viscosity. CF manifests clinically with chronic multisystem inflammation and recurrent infections. Nearly all children with CF have chronic sinusitis, and a large majority will have concurrent sinonasal polyposis. Chronic sinusitis and sinonasal polyposis in pediatric patients with CF can be managed conservatively initially, though most will fail medical management and require surgical intervention. Unfortunately, symptom resolution is marginal and polyp recurrence rates are high. Currently, no cure exists for CF and the mainstay of treatment is to provide symptomatic relief, and minimize disease morbidity.

Original languageEnglish (US)
Title of host publicationPediatric and Adult SinoNasal Disorders
PublisherNova Science Publishers, Inc.
Number of pages9
ISBN (Print)9781634822404, 9781634822220
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Rhinosinusitis in the pediatric patient with cystic fibrosis'. Together they form a unique fingerprint.

Cite this