Rhinosinusitis in the pediatric patient with cystic fibrosis

Christopher Fundakowski, Rosemary Ojo, Ramzi T Younis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cystic fibrosis (CF) is a common autosomal recessive genetic disorder where a deletion mutation and subsequent downstream alteration in transmembrane regulator proteins results in increased mucus viscosity. CF manifests clinically with chronic multisystem inflammation and recurrent infections. Nearly all children with CF have chronic sinusitis, and a large majority will have concurrent sinonasal polyposis. Chronic sinusitis and sinonasal polyposis in pediatric patients with CF can be managed conservatively initially, though most will fail medical management and require surgical intervention. Unfortunately, symptom resolution is marginal and polyp recurrence rates are high. Currently, no cure exists for CF and the mainstay of treatment is to provide symptomatic relief, and minimize disease morbidity.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalCurrent Pediatric Reviews
Volume10
Issue number3
StatePublished - Jan 1 2014

Fingerprint

Cystic Fibrosis
Pediatrics
Sinusitis
Inborn Genetic Diseases
Sequence Deletion
Mucus
Polyps
Viscosity
Inflammation
Morbidity
Recurrence
Infection
Proteins
Therapeutics

Keywords

  • Cystic fibrosis
  • Pediatric
  • Rhinosinusitis
  • Sinusitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rhinosinusitis in the pediatric patient with cystic fibrosis. / Fundakowski, Christopher; Ojo, Rosemary; Younis, Ramzi T.

In: Current Pediatric Reviews, Vol. 10, No. 3, 01.01.2014, p. 198-201.

Research output: Contribution to journalArticle

Fundakowski, Christopher ; Ojo, Rosemary ; Younis, Ramzi T. / Rhinosinusitis in the pediatric patient with cystic fibrosis. In: Current Pediatric Reviews. 2014 ; Vol. 10, No. 3. pp. 198-201.
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