Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation

Shivam Joshi, Rajinikanth Ayyathurai, Ahmed Eldefrawy, Jason Aminsharifi, Obi Ekwenna, Junichiro Sageshima, Linda J Chen, George W Burke, Gaetano Ciancio

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. Methods: We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. Results: Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. Conclusion: Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.

Original languageEnglish
Pages (from-to)1107-1111
Number of pages5
JournalInternational Urology and Nephrology
Volume44
Issue number4
DOIs
StatePublished - Aug 1 2012

Fingerprint

Rhabdomyolysis
Acute Kidney Injury
Tissue Donors
Kidney
Creatinine
Perfusion
Myoglobin
Myoglobinuria
Delayed Graft Function
Transplants
Pulsatile Flow
Phosphotransferases
Transplantation
Serum

Keywords

  • Acute kidney injury
  • Expanded criteria donor
  • Kidney transplantation
  • Machine perfusion
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation. / Joshi, Shivam; Ayyathurai, Rajinikanth; Eldefrawy, Ahmed; Aminsharifi, Jason; Ekwenna, Obi; Sageshima, Junichiro; Chen, Linda J; Burke, George W; Ciancio, Gaetano.

In: International Urology and Nephrology, Vol. 44, No. 4, 01.08.2012, p. 1107-1111.

Research output: Contribution to journalArticle

Joshi, Shivam ; Ayyathurai, Rajinikanth ; Eldefrawy, Ahmed ; Aminsharifi, Jason ; Ekwenna, Obi ; Sageshima, Junichiro ; Chen, Linda J ; Burke, George W ; Ciancio, Gaetano. / Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation. In: International Urology and Nephrology. 2012 ; Vol. 44, No. 4. pp. 1107-1111.
@article{8a6c2255d7f74df89fb74f014483a0ce,
title = "Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation",
abstract = "Purpose Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. Methods: We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. Results: Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. Conclusion: Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.",
keywords = "Acute kidney injury, Expanded criteria donor, Kidney transplantation, Machine perfusion, Rhabdomyolysis",
author = "Shivam Joshi and Rajinikanth Ayyathurai and Ahmed Eldefrawy and Jason Aminsharifi and Obi Ekwenna and Junichiro Sageshima and Chen, {Linda J} and Burke, {George W} and Gaetano Ciancio",
year = "2012",
month = "8",
day = "1",
doi = "10.1007/s11255-012-0185-1",
language = "English",
volume = "44",
pages = "1107--1111",
journal = "International Urology and Nephrology",
issn = "0301-1623",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation

AU - Joshi, Shivam

AU - Ayyathurai, Rajinikanth

AU - Eldefrawy, Ahmed

AU - Aminsharifi, Jason

AU - Ekwenna, Obi

AU - Sageshima, Junichiro

AU - Chen, Linda J

AU - Burke, George W

AU - Ciancio, Gaetano

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Purpose Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. Methods: We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. Results: Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. Conclusion: Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.

AB - Purpose Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. Methods: We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. Results: Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. Conclusion: Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.

KW - Acute kidney injury

KW - Expanded criteria donor

KW - Kidney transplantation

KW - Machine perfusion

KW - Rhabdomyolysis

UR - http://www.scopus.com/inward/record.url?scp=84867897716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867897716&partnerID=8YFLogxK

U2 - 10.1007/s11255-012-0185-1

DO - 10.1007/s11255-012-0185-1

M3 - Article

C2 - 22552709

AN - SCOPUS:84867897716

VL - 44

SP - 1107

EP - 1111

JO - International Urology and Nephrology

JF - International Urology and Nephrology

SN - 0301-1623

IS - 4

ER -