RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank

Umberto Nanni, Antonella Spila, Silvia Riondino, Maria Giovanna Valente, Paolo Somma, Mauro Iacoboni, Jhessica Alessandroni, Veronica Papa, David Della Morte, Raffaele Palmirotta, Patrizia Ferroni, Mario Roselli, Fiorella Guadagni

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Biospecimen quality is crucial for clinical and translational research and its loss is one of the main obstacles to experimental activities. Beside the quality of samples, preanalytical variations render the results derived from specimens of different biobanks or even within the same biobank incomparable. Specimens collected along the years should be managed with a heterogeneous life cycle. Hence, we propose to collect detailed data concerning the whole life cycle of stored samples employing radio-frequency identification (RFID) technology. Methods: We describe the processing chain of blood biosamples that is operative at the biobank of IRCSS San Raffaele, Rome, Italy (BioBIM). We focus on the problem of tracing the stages following automated preanalytical processing: we collected the time stamps of all events that could affect the biological quality of the specimens by means of RFID tags and readers. Results: We developed a pilot study on a fragment of the life cycle, namely the storage between the end of the preanalytics and the beginning of the analytics, which is usually not traced by automated tools because it typically includes manual handling. By adopting RFID devices we identified the possible critical time delays. At 1, 3 and 6 months RFID-tagged specimens cryopreserved at -80°C were successfully read. Conclusions: We were able to record detailed information about the storage phases and a fully documented specimen life cycle. This will allow us to promote and tune up the best practices in biobanking because i) it will be possible to classify sample features with a sharper resolution, which allows future utilization of stored material; ii) cost-effective policies can be adopted in processing, storing and selecting specimens; iii) after using each aliquot, we can study the life cycle of the specimen with a possible feedback on the procedures.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalInternational Journal of Biological Markers
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2011

Fingerprint

Radio Frequency Identification Device
Life Cycle Stages
Radio frequency identification (RFID)
Quality Control
Quality control
Life cycle
Quality of Life
Processing
Translational Medical Research
Information Storage and Retrieval
Practice Guidelines
Italy
Time delay
Blood
Technology
Feedback
Costs and Cost Analysis
Costs

Keywords

  • Biobank
  • Radio-frequency identification (rfid)
  • Specimen collection
  • Specimen retrieval

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Nanni, U., Spila, A., Riondino, S., Valente, M. G., Somma, P., Iacoboni, M., ... Guadagni, F. (2011). RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank. International Journal of Biological Markers, 26(2), 129-135. https://doi.org/10.5301/JBM.2011.8323

RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank. / Nanni, Umberto; Spila, Antonella; Riondino, Silvia; Valente, Maria Giovanna; Somma, Paolo; Iacoboni, Mauro; Alessandroni, Jhessica; Papa, Veronica; Della Morte, David; Palmirotta, Raffaele; Ferroni, Patrizia; Roselli, Mario; Guadagni, Fiorella.

In: International Journal of Biological Markers, Vol. 26, No. 2, 01.04.2011, p. 129-135.

Research output: Contribution to journalArticle

Nanni, U, Spila, A, Riondino, S, Valente, MG, Somma, P, Iacoboni, M, Alessandroni, J, Papa, V, Della Morte, D, Palmirotta, R, Ferroni, P, Roselli, M & Guadagni, F 2011, 'RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank', International Journal of Biological Markers, vol. 26, no. 2, pp. 129-135. https://doi.org/10.5301/JBM.2011.8323
Nanni, Umberto ; Spila, Antonella ; Riondino, Silvia ; Valente, Maria Giovanna ; Somma, Paolo ; Iacoboni, Mauro ; Alessandroni, Jhessica ; Papa, Veronica ; Della Morte, David ; Palmirotta, Raffaele ; Ferroni, Patrizia ; Roselli, Mario ; Guadagni, Fiorella. / RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank. In: International Journal of Biological Markers. 2011 ; Vol. 26, No. 2. pp. 129-135.
@article{23a1fc95be9f42ad87b8654d3b237695,
title = "RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank",
abstract = "Background: Biospecimen quality is crucial for clinical and translational research and its loss is one of the main obstacles to experimental activities. Beside the quality of samples, preanalytical variations render the results derived from specimens of different biobanks or even within the same biobank incomparable. Specimens collected along the years should be managed with a heterogeneous life cycle. Hence, we propose to collect detailed data concerning the whole life cycle of stored samples employing radio-frequency identification (RFID) technology. Methods: We describe the processing chain of blood biosamples that is operative at the biobank of IRCSS San Raffaele, Rome, Italy (BioBIM). We focus on the problem of tracing the stages following automated preanalytical processing: we collected the time stamps of all events that could affect the biological quality of the specimens by means of RFID tags and readers. Results: We developed a pilot study on a fragment of the life cycle, namely the storage between the end of the preanalytics and the beginning of the analytics, which is usually not traced by automated tools because it typically includes manual handling. By adopting RFID devices we identified the possible critical time delays. At 1, 3 and 6 months RFID-tagged specimens cryopreserved at -80°C were successfully read. Conclusions: We were able to record detailed information about the storage phases and a fully documented specimen life cycle. This will allow us to promote and tune up the best practices in biobanking because i) it will be possible to classify sample features with a sharper resolution, which allows future utilization of stored material; ii) cost-effective policies can be adopted in processing, storing and selecting specimens; iii) after using each aliquot, we can study the life cycle of the specimen with a possible feedback on the procedures.",
keywords = "Biobank, Radio-frequency identification (rfid), Specimen collection, Specimen retrieval",
author = "Umberto Nanni and Antonella Spila and Silvia Riondino and Valente, {Maria Giovanna} and Paolo Somma and Mauro Iacoboni and Jhessica Alessandroni and Veronica Papa and {Della Morte}, David and Raffaele Palmirotta and Patrizia Ferroni and Mario Roselli and Fiorella Guadagni",
year = "2011",
month = "4",
day = "1",
doi = "10.5301/JBM.2011.8323",
language = "English",
volume = "26",
pages = "129--135",
journal = "International Journal of Biological Markers",
issn = "0393-6155",
publisher = "Wichtig Publishing",
number = "2",

}

TY - JOUR

T1 - RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank

AU - Nanni, Umberto

AU - Spila, Antonella

AU - Riondino, Silvia

AU - Valente, Maria Giovanna

AU - Somma, Paolo

AU - Iacoboni, Mauro

AU - Alessandroni, Jhessica

AU - Papa, Veronica

AU - Della Morte, David

AU - Palmirotta, Raffaele

AU - Ferroni, Patrizia

AU - Roselli, Mario

AU - Guadagni, Fiorella

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Background: Biospecimen quality is crucial for clinical and translational research and its loss is one of the main obstacles to experimental activities. Beside the quality of samples, preanalytical variations render the results derived from specimens of different biobanks or even within the same biobank incomparable. Specimens collected along the years should be managed with a heterogeneous life cycle. Hence, we propose to collect detailed data concerning the whole life cycle of stored samples employing radio-frequency identification (RFID) technology. Methods: We describe the processing chain of blood biosamples that is operative at the biobank of IRCSS San Raffaele, Rome, Italy (BioBIM). We focus on the problem of tracing the stages following automated preanalytical processing: we collected the time stamps of all events that could affect the biological quality of the specimens by means of RFID tags and readers. Results: We developed a pilot study on a fragment of the life cycle, namely the storage between the end of the preanalytics and the beginning of the analytics, which is usually not traced by automated tools because it typically includes manual handling. By adopting RFID devices we identified the possible critical time delays. At 1, 3 and 6 months RFID-tagged specimens cryopreserved at -80°C were successfully read. Conclusions: We were able to record detailed information about the storage phases and a fully documented specimen life cycle. This will allow us to promote and tune up the best practices in biobanking because i) it will be possible to classify sample features with a sharper resolution, which allows future utilization of stored material; ii) cost-effective policies can be adopted in processing, storing and selecting specimens; iii) after using each aliquot, we can study the life cycle of the specimen with a possible feedback on the procedures.

AB - Background: Biospecimen quality is crucial for clinical and translational research and its loss is one of the main obstacles to experimental activities. Beside the quality of samples, preanalytical variations render the results derived from specimens of different biobanks or even within the same biobank incomparable. Specimens collected along the years should be managed with a heterogeneous life cycle. Hence, we propose to collect detailed data concerning the whole life cycle of stored samples employing radio-frequency identification (RFID) technology. Methods: We describe the processing chain of blood biosamples that is operative at the biobank of IRCSS San Raffaele, Rome, Italy (BioBIM). We focus on the problem of tracing the stages following automated preanalytical processing: we collected the time stamps of all events that could affect the biological quality of the specimens by means of RFID tags and readers. Results: We developed a pilot study on a fragment of the life cycle, namely the storage between the end of the preanalytics and the beginning of the analytics, which is usually not traced by automated tools because it typically includes manual handling. By adopting RFID devices we identified the possible critical time delays. At 1, 3 and 6 months RFID-tagged specimens cryopreserved at -80°C were successfully read. Conclusions: We were able to record detailed information about the storage phases and a fully documented specimen life cycle. This will allow us to promote and tune up the best practices in biobanking because i) it will be possible to classify sample features with a sharper resolution, which allows future utilization of stored material; ii) cost-effective policies can be adopted in processing, storing and selecting specimens; iii) after using each aliquot, we can study the life cycle of the specimen with a possible feedback on the procedures.

KW - Biobank

KW - Radio-frequency identification (rfid)

KW - Specimen collection

KW - Specimen retrieval

UR - http://www.scopus.com/inward/record.url?scp=79959299056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959299056&partnerID=8YFLogxK

U2 - 10.5301/JBM.2011.8323

DO - 10.5301/JBM.2011.8323

M3 - Article

C2 - 21574153

AN - SCOPUS:79959299056

VL - 26

SP - 129

EP - 135

JO - International Journal of Biological Markers

JF - International Journal of Biological Markers

SN - 0393-6155

IS - 2

ER -