Revised translation start site for secM defines an atypical signal peptide that regulates Escherichia coli secA expression

S. Sarker, K. E. Rudd, D. Oliver

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The secretion-responsive regulation of Escherichia coli secA occurs by coupling its translation to the translation and secretion of an upstream regulator, secM (formerly geneX). We revise the translational start site for secM, defining a new signal peptide sequence with an extended amino-terminal region. Mutational studies indicate that certain atypical amino acyl residues within this extended region are critical for proper secA regulation.

Original languageEnglish (US)
Pages (from-to)5592-5595
Number of pages4
JournalJournal of bacteriology
Volume182
Issue number19
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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