Review of the literature: Severe hyperphosphatemia

L. Thatte, J. R. Oster, I. Singer, J. J. Bourgoignie, L. M. Fishman, B. A. Roos

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


A patient with a markedly elevated serum phosphorus level (23.9 mg/dL) is described, followed by a brief review of severe hyperphosphatemia. Elevated serum phosphorus levels may be artifactual or true. True hyperphosphatemia is usefully subdivided according to (a) whether phosphorus is added to the extracellular fluid from a variety of exogenous or endogenous sources, or (b) whether the urinary excretion of phosphorus is reduced from either decreased glomerular filtration or increased tubular reabsorption. Severe hyperphosphatemia, defined herein as levels of 14 mg/dL or higher, is almost invariably multifactorial-usually resulting from addition of phosphorus to the extracellular fluid together with decreased phosphorus excretion. The hyperphosphatemia of the patient described herein appeared to result from a combination of dietary phosphorus supplementation, acute renal failure, acute pancreatitis, and ischemic bowel disease, complicated by lactic acidosis.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalAmerican Journal of the Medical Sciences
Issue number4
StatePublished - 1995
Externally publishedYes


  • Acute renal failure
  • Anion gap
  • Hypermagnesemia
  • Hyperphosphatemia
  • Lactic acidosis

ASJC Scopus subject areas

  • Medicine(all)


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