Review of the history and current status of cell-transplant approaches for the management of neuropathic pain

Mary J. Eaton, Yerko Berrocal, Stacey Q. Wolfe, Eva Widerstrom-Noga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Treatment of sensory neuropathies, whether inherited or caused by trauma, the progress of diabetes, or other disease states, are among the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord would be the logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the transplant of cells or a cell line to treat human disease. The history of the research and development of useful cell-transplant-based approaches offers an understanding of the advantages and problems associated with these technologies, but as an adjuvant or replacement for current pharmacological treatments, cell therapy is a likely near future clinical tool for improved health care.

Original languageEnglish
Article number263972
JournalPain Research and Treatment
Volume2012
DOIs
StatePublished - Dec 1 2012

Fingerprint

Neuralgia
History
Cell- and Tissue-Based Therapy
Transplants
Chronic Pain
Analgesics
Spinal Cord
Therapeutics
Clinical Trials
Pharmacology
Technology
Delivery of Health Care
Cell Line
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Review of the history and current status of cell-transplant approaches for the management of neuropathic pain. / Eaton, Mary J.; Berrocal, Yerko; Wolfe, Stacey Q.; Widerstrom-Noga, Eva.

In: Pain Research and Treatment, Vol. 2012, 263972, 01.12.2012.

Research output: Contribution to journalArticle

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