Review of the history and current status of cell-transplant approaches for the management of neuropathic pain

Mary J. Eaton, Yerko Berrocal, Stacey Q. Wolfe, Eva Widerstrom-Noga

Research output: Contribution to journalArticle

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Treatment of sensory neuropathies, whether inherited or caused by trauma, the progress of diabetes, or other disease states, are among the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord would be the logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the transplant of cells or a cell line to treat human disease. The history of the research and development of useful cell-transplant-based approaches offers an understanding of the advantages and problems associated with these technologies, but as an adjuvant or replacement for current pharmacological treatments, cell therapy is a likely near future clinical tool for improved health care.

Original languageEnglish
Article number263972
JournalPain Research and Treatment
StatePublished - Dec 1 2012


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

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