Review of results from the tube versus trabeculectomy study

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Purpose of review: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin (MMC) in eyes with previous cataract and/or unsuccessful glaucoma surgery. This article reviews published results from the TVT Study. Recent findings: Tube-shunt surgery had a higher success rate than trabeculectomy with MMC during the first 3 years of follow-up. Trabeculectomy with MMC produced greater intraocular pressure (IOP) reduction in the early postoperative period compared with tube-shunt placement, but similar IOPs were observed after 3 months. Tube-shunt surgery was associated with greater use of adjunctive-medical therapy than trabeculectomy with MMC during the first 2 years of the study, but no difference in medication use was seen at 3 years. The incidence of postoperative complications was higher after trabeculectomy with MMC compared with tube-shunt surgery, but serious complications associated with vision loss and/or reoperation developed with similar frequency after both surgical procedures. No difference in the rate of vision loss was present following trabeculectomy with MMC and tube-shunt surgery after 3 years of follow-up. Cataract progression was common, but occurred with similar frequency with both procedures. Summary: Intermediate-term results of the TVT Study support the expanded use of tube shunts beyond refractory glaucomas. Tube-shunt surgery is an appropriate surgical option in patients who have undergone prior cataract and/or unsuccessful filtering surgery.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalCurrent Opinion in Ophthalmology
Volume21
Issue number2
DOIs
StatePublished - Mar 1 2010

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Trabeculectomy
Mitomycin
Cataract
Glaucoma
Filtering Surgery
Intraocular Pressure
Reoperation
Postoperative Period
Randomized Controlled Trials
Safety
Incidence

Keywords

  • Glaucoma surgery
  • Trabeculectomy
  • Tube shunt

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Review of results from the tube versus trabeculectomy study. / Gedde, Steven J; Heuer, Dale K.; Parrish, Richard K.

In: Current Opinion in Ophthalmology, Vol. 21, No. 2, 01.03.2010, p. 123-128.

Research output: Contribution to journalArticle

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