Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting

George W Burke, G. M. Vercellotti, R. L. Simmons, R. B. Howe, D. M. Canafax, J. S. Najarian

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We present two instances of pancytopenia in kidney transplant patients associated with a course of OKT3 therapy. In one case, OKT3 was used prophylactically, in the other therapeutically to treat biopsy-proved rejection. They both occurred in the setting of multi-drug immunosuppression, including Minnesota anti-lymphocyte globulin, and recovered with supportive therapy. Previous antihypertensive medication, antibiotics, and azathioprine were restarted without hematologic sequelae. Evidence implicating OKT3, and resultant gamma-interferon-induced marrow suppression is discussed.

Original languageEnglish
Pages (from-to)403-408
Number of pages6
JournalTransplantation
Volume48
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Muromonab-CD3
Pancytopenia
Homologous Transplantation
Kidney
Globulins
Azathioprine
Immunosuppression
Antihypertensive Agents
Interferon-gamma
Bone Marrow
Lymphocytes
Anti-Bacterial Agents
Transplants
Biopsy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Burke, G. W., Vercellotti, G. M., Simmons, R. L., Howe, R. B., Canafax, D. M., & Najarian, J. S. (1989). Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting. Transplantation, 48(3), 403-408.

Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting. / Burke, George W; Vercellotti, G. M.; Simmons, R. L.; Howe, R. B.; Canafax, D. M.; Najarian, J. S.

In: Transplantation, Vol. 48, No. 3, 01.01.1989, p. 403-408.

Research output: Contribution to journalArticle

Burke, GW, Vercellotti, GM, Simmons, RL, Howe, RB, Canafax, DM & Najarian, JS 1989, 'Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting', Transplantation, vol. 48, no. 3, pp. 403-408.
Burke GW, Vercellotti GM, Simmons RL, Howe RB, Canafax DM, Najarian JS. Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting. Transplantation. 1989 Jan 1;48(3):403-408.
Burke, George W ; Vercellotti, G. M. ; Simmons, R. L. ; Howe, R. B. ; Canafax, D. M. ; Najarian, J. S. / Reversible pancytopenia following OKT3. Use in the context of multidrug immunossuppression for kidney allografting. In: Transplantation. 1989 ; Vol. 48, No. 3. pp. 403-408.
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