Reversible pancytopenia following OKT3: Use in the context of multidrug immunosuppression for kidney allografting

George W. Burke, Gregory M. Vercellotti, Richard L. Simmons, Robert B. Howe, Daniel M. Canafax, John S. Najarían

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We present two instances of pancytopenia in kidney transplant patients associated with a course of OKT3 therapy. In one case, OKT3 was used prophylactically, in the other therapeutically to treat biopsy-proved rejection. They both occurred in the setting of multi-drug immunosuppression, including Minnesota anti-lymphocyte globulin, and recovered with supportive therapy. Previous antihypertensive medication, antibiotics, and azathioprine were restarted without hematologic sequelae. Evidence implicating OKT3, and resultant gamma-interferon-induced marrow suppression is discussed.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalTransplantation
Volume48
Issue number3
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Transplantation

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