Reversible Bone Marrow Suppression From Chloramphenicol: A Consequence of Mitochondrial Injury

Adel A. Yunis, Una S. Smith, Alberto Restrepo

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Chloramphenicol is a potent inhibitor of mitochondrial protein synthesis. Recent studies on rabbit and human bone marrow mitochondria strongly suggest a relationship between inhibition of protein synthesis and myelotoxicity from chloramphenicol. A thorough electron microscopic study of bone marrow mitochondria derived from patients receiving chloramphenicol indicates that this drug induces ultrastructural modifications resulting in an increase in the density of the mitochondrial matrix. Excellent correlation is observed between the extent of the ultrastructural changes and serum levels of free chloramphenicol. The results lend further support to the hypothesis that reversible bone marrow suppression from chloramphenicol results from inhibition by the drug of mitochondrial protein synthesis.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalArchives of internal medicine
Volume126
Issue number2
DOIs
StatePublished - Aug 1970

ASJC Scopus subject areas

  • Internal Medicine

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