Reverse transcriptase mutations in HIV-1-infected children treated with zidovudine

Ayce Ünal, Eric Lorenzo, Michael Brown, Laurette Smith, Suzanne Matsuura, Gwendolyn Scott, Walter Scott

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutations were detected in DNA from peripheral blood mononuclear cells from 11 of 12 HIV-1-infected children after 11-20 months of zidovudine monotherapy. The number of children with mutations detected at each codon were as follows: codon 41, 4; codon 67, 2: codon 70, 7; codon 215. 7; codon 219. 0. Codon 41 mutations were found only in the presence of a codon 215 mutation and in the absence of a codon 70 mutation. The codon 41/215 mutant combination was associated with decline in weight-for-age z score during therapy, weight <10th percentile. CD4+ cell counts <3rd percentile, and immune-complex dissociated HIV-1 p24 antigen (ICD p24 Ag) levels >100 pg/ml. Patients developing the codon 70 mutation tended to have body weight >30th percentile, CD4+ cell counts >25th percentile, and ICD p24 Ag <100 pg/ml. The codon 41 mutation was associated with clinical deterioration during a 6- month followup period.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume13
Issue number2
DOIs
StatePublished - 1996

Keywords

  • Clinical progression
  • Pediatric HIV infection
  • Reverse transcriptase mutations
  • Zidovudine resistance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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