Abstract
We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 775-780 |
| Number of pages | 6 |
| Journal | Experimental Hematology |
| Volume | 9 |
| Issue number | 7 |
| State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- Molecular Biology
- Hematology
- Genetics
- Cell Biology
- Cancer Research
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Cite this
Miller, A. M., & Yunis, A. A. (1981). Reversal of in vitro drug induced myeloid suppression by lithium. Experimental Hematology, 9(7), 775-780.