Reversal of in vitro drug induced myeloid suppression by lithium

A. M. Miller, Adel A Yunis

Research output: Contribution to journalArticle

Abstract

We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalExperimental Hematology
Volume9
Issue number7
StatePublished - 1981

Fingerprint

Lithium
Chlorpromazine
Chloramphenicol
Pharmaceutical Preparations
Agar
Bone Marrow
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Reversal of in vitro drug induced myeloid suppression by lithium. / Miller, A. M.; Yunis, Adel A.

In: Experimental Hematology, Vol. 9, No. 7, 1981, p. 775-780.

Research output: Contribution to journalArticle

Miller, AM & Yunis, AA 1981, 'Reversal of in vitro drug induced myeloid suppression by lithium', Experimental Hematology, vol. 9, no. 7, pp. 775-780.
Miller, A. M. ; Yunis, Adel A. / Reversal of in vitro drug induced myeloid suppression by lithium. In: Experimental Hematology. 1981 ; Vol. 9, No. 7. pp. 775-780.
@article{c09023cad1ff4b9194c3403aa8e29521,
title = "Reversal of in vitro drug induced myeloid suppression by lithium",
abstract = "We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40{\%} and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.",
author = "Miller, {A. M.} and Yunis, {Adel A}",
year = "1981",
language = "English (US)",
volume = "9",
pages = "775--780",
journal = "Experimental Hematology",
issn = "0301-472X",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Reversal of in vitro drug induced myeloid suppression by lithium

AU - Miller, A. M.

AU - Yunis, Adel A

PY - 1981

Y1 - 1981

N2 - We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.

AB - We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.

UR - http://www.scopus.com/inward/record.url?scp=0019490715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019490715&partnerID=8YFLogxK

M3 - Article

C2 - 7318979

AN - SCOPUS:0019490715

VL - 9

SP - 775

EP - 780

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 7

ER -