Reversal of in vitro drug induced myeloid suppression by lithium

A. M. Miller; A. A. Yunis

Reversal of in vitro drug induced myeloid suppression by lithium

A. M. Miller, A. A. Yunis

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10^-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.

Original language	English (US)
Pages (from-to)	775-780
Number of pages	6
Journal	Experimental Hematology
Volume	9
Issue number	7
State	Published - 1981

ASJC Scopus subject areas

Molecular Biology
Hematology
Genetics
Cell Biology
Cancer Research

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abstract = "We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.",

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