Abstract
We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 775-780 |
| Number of pages | 6 |
| Journal | Experimental Hematology |
| Volume | 9 |
| Issue number | 7 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Genetics
- Hematology
- Oncology
- Transplantation
Cite this
Reversal of in vitro drug induced myeloid suppression by lithium. / Miller, A. M.; Yunis, Adel A.
In: Experimental Hematology, Vol. 9, No. 7, 1981, p. 775-780.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversal of in vitro drug induced myeloid suppression by lithium
AU - Miller, A. M.
AU - Yunis, Adel A
PY - 1981
Y1 - 1981
N2 - We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.
AB - We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.
UR - http://www.scopus.com/inward/record.url?scp=0019490715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019490715&partnerID=8YFLogxK
M3 - Article
C2 - 7318979
AN - SCOPUS:0019490715
VL - 9
SP - 775
EP - 780
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 7
ER -