Reversal of in vitro drug induced myeloid suppression by lithium

A. M. Miller, A. A. Yunis

Research output: Contribution to journalArticle

Abstract

We have investigated the ability of lithium to protect against chloramphenicol (CAP) and chlorpromazine (CPZ) induced suppression of human myeloid colony forming cells (CFU(C)). In the standard semi-solid agar assay for human CFU(C) lithium (0.5-10 x 10-3 M) enhances myeloid colony formation by 30-40% and protects against CAP and CPZ induced suppression, in a manner similar to increasing CSF concentrations. Prior depletion of adherent cell populations from human marrow eliminates the lithium effects, thus suggesting a primary action through CSF production.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalExperimental Hematology
Volume9
Issue number7
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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