Reversal of graft-versus-host disease with infusion of autologous bone marrow

Camillo Ricordi, Anreas G. Tzakis, Adriana Zeevi, Witold B. Rybka, Anthony J. Demetris, Paulo A.C. Fontes, Michael A. Nalesnik, Massimo Trucco, Ferdinand O. Ukah, Edward D. Ball, Edward E. Mullen, Ignazio R. Marino, John J. Fung, Thomas E. Starzl

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalCell transplantation
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1994

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Keywords

  • Bone marrow Human
  • Graft-versus-host
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Cell Biology

Cite this

Ricordi, C., Tzakis, A. G., Zeevi, A., Rybka, W. B., Demetris, A. J., Fontes, P. A. C., Nalesnik, M. A., Trucco, M., Ukah, F. O., Ball, E. D., Mullen, E. E., Marino, I. R., Fung, J. J., & Starzl, T. E. (1994). Reversal of graft-versus-host disease with infusion of autologous bone marrow. Cell transplantation, 3(2), 187-192. https://doi.org/10.1177/096368979400300207