Abstract
Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
Original language | English (US) |
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Pages (from-to) | 779-783 |
Number of pages | 5 |
Journal | Behavioral Neuroscience |
Volume | 103 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Behavioral Neuroscience