Abstract
Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
| Original language | English |
|---|---|
| Pages (from-to) | 779-783 |
| Number of pages | 5 |
| Journal | Behavioral Neuroscience |
| Volume | 103 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine. / Connor, Donald J.; Harrell, Lindy E.; Jope, Richard S.
In: Behavioral Neuroscience, Vol. 103, No. 4, 01.08.1989, p. 779-783.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine
AU - Connor, Donald J.
AU - Harrell, Lindy E.
AU - Jope, Richard S
PY - 1989/8/1
Y1 - 1989/8/1
N2 - Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
AB - Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
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U2 - 10.1037/0735-7044.103.4.779
DO - 10.1037/0735-7044.103.4.779
M3 - Article
VL - 103
SP - 779
EP - 783
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 4
ER -