Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine

Donald J. Connor, Lindy E. Harrell, Richard S. Jope

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.

Original languageEnglish (US)
Pages (from-to)779-783
Number of pages5
JournalBehavioral Neuroscience
Issue number4
StatePublished - Aug 1989
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience


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