Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine

Donald J. Connor, Lindy E. Harrell, Richard S Jope

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p < .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.

Original languageEnglish
Pages (from-to)779-783
Number of pages5
JournalBehavioral Neuroscience
Volume103
Issue number4
DOIs
StatePublished - Aug 1 1989
Externally publishedYes

Fingerprint

Deferoxamine
Aluminum
Poisons
Chelating Agents
Drinking Water
Sprague Dawley Rats
Injections
Therapeutics

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine. / Connor, Donald J.; Harrell, Lindy E.; Jope, Richard S.

In: Behavioral Neuroscience, Vol. 103, No. 4, 01.08.1989, p. 779-783.

Research output: Contribution to journalArticle

Connor, Donald J. ; Harrell, Lindy E. ; Jope, Richard S. / Reversal of an Aluminum-Induced Behavioral Deficit by Administration of Deferoxamine. In: Behavioral Neuroscience. 1989 ; Vol. 103, No. 4. pp. 779-783.
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