@article{494753d034c04da7bd5db72eb1988cfd,
title = "Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases",
abstract = "We previously reported a linkage region on chromosome 10q for age-at-onset (AAO) of Alzheimer (AD) and Parkinson (PD) diseases. Glutathione S-transferase, omega-1 (GSTO1) and the adjacent gene GSTO2, located in this linkage region, were then reported to associate with AAO of AD and PD. To examine whether GSTO1 and GSTO2 (hereafter referred to as GSTO1h) are responsible for the linkage evidence, we identified 39 families in AD that lead to our previous linkage and association findings. The evidence of linkage and association was markedly diminished after removing these 39 families from the analyses, thus providing support that GSTO1h drives the original linkage results. The maximum average AAO delayed by GSTO1h SNP 7-1 (rs4825, A nucleotide) was 6.8 (±4.41) years for AD and 8.6(±5.71) for PD, respectively. This is comparable to the magnitude of AAO difference by APOE-4 in these same AD and PD families. These findings suggest the presence of genetic heterogeneity for GSTO1h's effect on AAO, and support GSTO1h's role in modifying AAO in these two disorders.",
keywords = "Age-at-onset, Alzheimer disease, Association, GSTO1, Linkage",
author = "Li, {Yi Ju} and Scott, {William K.} and Ling Zhang and Lin, {Ping I.} and Oliveira, {Sofia A.} and Tara Skelly and Doraiswamy, {Maurali P.} and Welsh-Bohmer, {Kathleen A.} and Martin, {Eden R.} and Haines, {Jonathan L.} and Pericak-Vance, {Margaret A.} and Vance, {Jeffery M.}",
note = "Funding Information: We thank the patients with Alzheimer disease and their families whose help and participation made this work possible. We also thank the personnel of the Duke Center for Human Genetics, Vanderbilt Center for Human Genetics Research, and the Joseph and Kathleen Bryan Alzheimer Disease Research Center. Furthermore, we thank Dr. Donald E. Schmechel for his help on our AD ascertainment. This work was supported by the National Institute of Health (NIH) NS311530 (JMV), AG021547 (MPV), AG19757 (MPV), and AG05128 (MPV) grants; a T.L.L. Temple Award (TLL-97-012) and a Zenith Award (ZEN-01-2935) from the Alzheimer's Association (MPV); the 2001 Louis D. award from the Institut de France (MPV); an American Federation for Aging Research (AFAR) 2002 Research Grant (YJL); a New Investigator Research Grant Award (Hilles Families Foundation Award) from the Alzheimer's Association (YJL). We appreciate the biomaterial and clinical data contributed by Indiana Alzheimer's Disease Research Center National Cell Repository (IADRC). The National Institute of Mental Health (NIMH) data and biomaterials were collected in three projects that participated in the NIMH Alzheimer Disease Genetics Initiative. From 1991–1998, the Principal Investigators and Co-Investigators were: Massachusetts General Hospital, Boston, MA, U01 MH46281, Marilyn S. Albert, Ph.D., and Deborah Blacker, M.D., Sc.D.; Johns Hopkins University, Baltimore, MD, U01 MH46290, Susan S. Bassett, Ph.D., Gary A. Chase, Ph.D., and Marshal F. Folstein, M.D.; University of Alabama, Birmingham, AL, U01 MH46373, Rodney C.P. Go, Ph.D., and Lindy E. Harrell, M.D. ",
year = "2006",
month = aug,
doi = "10.1016/j.neurobiolaging.2005.05.013",
language = "English (US)",
volume = "27",
pages = "1087--1093",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "8",
}