Retrospective registration of X‐ray angiograms with MR images by using vessels as intrinsic landmarks

Noam Alperin, David N. Levin, Charles A. Pelizzari

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Conventional x-ray angiography (XRA) images are projections of the vasculature with high spatial and temporal resolution, while magnetic resonance (MR) angiography (MRA) and MR imaging data show the three-dimensional locations of vessels relative to brain parenchyma. The authors have developed a retrospective method of registering these studies, which makes it practical to produce multimodality displays of this complementary information. Registration was performed by matching vessels seen on both XRA and MRA images. First, the authors determined the coordinates of the center lines of a few "landmark" vessels on the XRA image and the three-dimensional locations of the corresponding intraluminal voxels in the MRA volume. Registration was performed by rotating and translating the MRA-MR imaging volume until the perspective projection of the MRA landmark vessels matched the corresponding vessel center lines on the XRA image. Experiments with phantoms and patients indicated that the two studies were registered with an average error of less than 2 mm. A linked-cursor display was developed to show correspondence between points on the registered XRA and MRA-MR images.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - 1994
Externally publishedYes


  • Cerebral blood vessels, MR, 17.12142
  • Image display
  • Image processing
  • Three‐dimensional imaging
  • Vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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