Retrospective assessment of islet cell autoantibodies in pancreas organ donors

Stavros Diamantopoulos, Gloria Allende, Joseph M. Ferreira, Gaetano Ciancio, George W. Burke, Alberto Pugliese

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

OBJECTIVE - Of deceased pancreas donors, 3-4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS - We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2- AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS - Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3-5.8 years after transplant. The recipient of the insulin-AAb-positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS - Single AAb positivity did not affect the outcome of pancreas transplantation in our study.

Original languageEnglish (US)
Pages (from-to)1741-1742
Number of pages2
JournalDiabetes care
Volume31
Issue number9
DOIs
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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