Retroperitoneal malignant meningioma: A light microscopic, immunohistochemical, and ultrastructural study

Monica Huszar, Julie C. Fanburg, G. Richard Dickersin, Jeffrey J. Kirshner, Andrew Rosenberg

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Malignant meningiomas are uncommon and rarely occur outside the central nervous system. We describe herein a morphologically unusual malignant neoplasm that arose in the retroperitoneum of a 25-year-old woman. The tumor was composed of sheets of epithelioid cells that were frequently arranged in prominent whorls. By electron microscopy, the neoplastic cells had long, tapering cell processes that formed numerous interdigitations: many junctions including desmosomes; and abundant intermediate filaments. Immunohistochemistry showed that the tumor cells expressed vimentin, keratin, and epithelial membrane antigen. Based on these findings, the neoplasm was classified as a malignant meningioma. According to our review of the literature, this is the first reported occurrence of a primary retroperitoneal meningothelial neoplasm and the second reported case of an ectopic meningioma that was malignant.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume20
Issue number4
DOIs
StatePublished - Apr 1 1996
Externally publishedYes

Fingerprint

Meningioma
Light
Retroperitoneal Neoplasms
Neoplasms
Epithelioid Cells
Mucin-1
Desmosomes
Intermediate Filaments
Vimentin
Keratins
Electron Microscopy
Central Nervous System
Immunohistochemistry

Keywords

  • Ectopic
  • Malignant meningioma
  • Retroperitoneum

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Retroperitoneal malignant meningioma : A light microscopic, immunohistochemical, and ultrastructural study. / Huszar, Monica; Fanburg, Julie C.; Dickersin, G. Richard; Kirshner, Jeffrey J.; Rosenberg, Andrew.

In: American Journal of Surgical Pathology, Vol. 20, No. 4, 01.04.1996, p. 492-499.

Research output: Contribution to journalArticle

Huszar, Monica ; Fanburg, Julie C. ; Dickersin, G. Richard ; Kirshner, Jeffrey J. ; Rosenberg, Andrew. / Retroperitoneal malignant meningioma : A light microscopic, immunohistochemical, and ultrastructural study. In: American Journal of Surgical Pathology. 1996 ; Vol. 20, No. 4. pp. 492-499.
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