Retrograde axonal transport of lead in rat sciatic nerve

Jitendra K. Baruah, Chaudri G. Rasool, Walter G. Bradley, Theodore L. Munsat

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


A wavelike pattern of retrograde axonal transport of lead was demonstrated in rat sciatic nerve after injection of 203Pb into the triceps surae muscle. The transport rate was about 10 mm per day, and the lead reached the spinal cord by 9 days after injection. The distribution of lead within the spinal cord indicated the possibility of retrograde axonal transport in the upper and lower motor neurons, which might explain how lead enters the central nervous system and could be related to the postulated role of lead in causing amyotrophic lateral sclerosis. Lead may be useful in investigating retrograde transport experimentally.

Original languageEnglish (US)
Pages (from-to)612-616
Number of pages5
Issue number5
StatePublished - May 1981
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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