Retrograde axonal transport of lead in rat sciatic nerve

J. K. Baruah, C. G. Rasool, Walter G Bradley, T. L. Munsat

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A wavelike pattern of retrograde axonal transport of lead was demonstrated in rat sciatic nerve after injection of 203Pb into the triceps surae muscle. The transport rate was about 10 mm per day, and the lead reached the spinal cord by 9 days after injection. The distribution of lead within the spinal cord indicated the possibility of retrograde axonal transport in the upper and lower motor neurons, which might explain how lead enters the central nervous system and could be related to the postulated role of lead in causing amyotrophic lateral sclerosis. Lead may be useful in investigating retrograde transport experimentally.

Original languageEnglish
Pages (from-to)612-616
Number of pages5
JournalNeurology
Volume31
Issue number5
StatePublished - Jan 1 1981
Externally publishedYes

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Axonal Transport
Sciatic Nerve
Spinal Cord
Injections
Amyotrophic Lateral Sclerosis
Motor Neurons
Lead
Central Nervous System
Muscles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Baruah, J. K., Rasool, C. G., Bradley, W. G., & Munsat, T. L. (1981). Retrograde axonal transport of lead in rat sciatic nerve. Neurology, 31(5), 612-616.

Retrograde axonal transport of lead in rat sciatic nerve. / Baruah, J. K.; Rasool, C. G.; Bradley, Walter G; Munsat, T. L.

In: Neurology, Vol. 31, No. 5, 01.01.1981, p. 612-616.

Research output: Contribution to journalArticle

Baruah, JK, Rasool, CG, Bradley, WG & Munsat, TL 1981, 'Retrograde axonal transport of lead in rat sciatic nerve', Neurology, vol. 31, no. 5, pp. 612-616.
Baruah JK, Rasool CG, Bradley WG, Munsat TL. Retrograde axonal transport of lead in rat sciatic nerve. Neurology. 1981 Jan 1;31(5):612-616.
Baruah, J. K. ; Rasool, C. G. ; Bradley, Walter G ; Munsat, T. L. / Retrograde axonal transport of lead in rat sciatic nerve. In: Neurology. 1981 ; Vol. 31, No. 5. pp. 612-616.
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