Retinoic acid-induced glandular metaplasia in mouse skin is linked to the dermal expression of retinoic acid receptor β mRNA

Jean P. Viallet, Esther Ruberte, Stanislas du Manoir, Andrée Krust, Arthur Zelent, Danielle Dhouailly

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The distribution of transcripts of nuclear (RARα, RARβ, and RARγ) and cytosolic (CRABP) retinoic acid receptors was analyzed in 13.5-day mouse embryo upper-lip skin, cultured in vitro for 48 hr with or without added retinoic acid. The results show a significant up-regulation of the transcription of the RARβ gene concomitant with the initiation of an alteration of hair vibrissae follicle development, leading, after transfer for 8 days to the chick embryo chorioallantoic membrane, to an exocrine-type gland morphogenesis.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalDevelopmental Biology
Volume144
Issue number2
DOIs
StatePublished - Apr 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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