Retinoic acid-induced embryopathy of the mouse inner ear

Dorothy A. Frenz, Wei Liu, Vera Galinovic-Schwartz, Thomas R. Van De Water

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Retinoic acid (RA) is an active metabolite of vitamin A that is teratogenic when present in excess during mammalian embryogenesis. We have investigated the effect of embryonic exposure to nonphysiological levels of all-trans RA on the development of the mouse inner ear. Dysmorphogenesis of both vestibular and auditory portions of the inner ear, and abnormal formation of the surrounding capsule are produced by exposure to teratogenic levels of RA at an embryonic age of 9 days (E9). There was no observable teratogenic effect of RA when administered at earlier (i.e., E7 or E8) or later (i.e., E10) stages of otic morphogenesis. We hypothesize that exposure to high levels of RA during a critical period of early otic morphogenesis interferes with the inductive tissue interactions required for inner ear development.

Original languageEnglish (US)
Pages (from-to)292-303
Number of pages12
JournalTeratology
Volume53
Issue number5
DOIs
StatePublished - May 1 1996

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

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    Frenz, D. A., Liu, W., Galinovic-Schwartz, V., & Van De Water, T. R. (1996). Retinoic acid-induced embryopathy of the mouse inner ear. Teratology, 53(5), 292-303. https://doi.org/10.1002/(SICI)1096-9926(199605)53:5<292::AID-TERA3>3.3.CO;2-C